Cargando…

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study

Prior evidence indicates the potential central role of the acid sphingomyelinase (ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a multicenter retrospective observational study including 72,105 adult patients with laboratory-confirmed SARS-CoV-2 infection who were admit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoertel, Nicolas, Rezaei, Katayoun, Sánchez-Rico, Marina, Delgado-Álvarez, Alfonso, Kornhuber, Johannes, Gulbins, Erich, Olfson, Mark, Ouazana-Vedrines, Charles, Carpinteiro, Alexander, Cougoule, Céline, Becker, Katrin Anne, Alvarado, Jesús M., Limosin, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458150/ https://www.ncbi.nlm.nih.gov/pubmed/37631022 http://dx.doi.org/10.3390/ph16081107

Ejemplares similares

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
por: Hoertel, Nicolas, et al.
Publicado: (2021)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality: Results from 49,089 COVID-19 inpatients
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
por: Carpinteiro, Alexander, et al.
Publicado: (2021)

Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2: Support for the FIASMA Model against COVID-19
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Antipsychotic use and 28-day Mortality in Patients Hospitalized with COVID-19: a multicenter observational retrospective study
por: Sánchez-Rico, Marina, et al.
Publicado: (2023)

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2: Support for the FIASMA Model against COVID-19
por: Hoertel, N., et al.
Publicado: (2023)

Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19: an observational multicenter study
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Association between benzodiazepine receptor agonist use and mortality in patients hospitalised for COVID-19: a multicentre observational study
por: Hoertel, N., et al.
Publicado: (2022)

Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID‐19: An Observational Multicenter Study
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

Comorbidity patterns and mortality among hospitalized patients with psychiatric disorders and COVID-19
por: Sánchez-Rico, Marina, et al.
Publicado: (2023)

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells
por: Avota, Elita, et al.
Publicado: (2011)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model
por: Péricat, David, et al.
Publicado: (2022)

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
por: Beckmann, Nadine, et al.
Publicado: (2014)

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells
por: Simonis, Alexander, et al.
Publicado: (2014)

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
por: Wilson, Gregory C., et al.
Publicado: (2023)

Regulation of hematogenous tumor metastasis by acid sphingomyelinase
por: Carpinteiro, Alexander, et al.
Publicado: (2015)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
por: Carpinteiro, Alexander, et al.
Publicado: (2020)

Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
por: Managò, Antonella, et al.
Publicado: (2015)

Outcomes associated with antidepressant treatment according to the number of prescriptions and treatment changes: 5-year follow-up of a nation-wide cohort study
por: Ouazana-Vedrines, Charles, et al.
Publicado: (2022)

Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells
por: Becker, Katrin Anne, et al.
Publicado: (2021)

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
por: Naser, Eyad, et al.
Publicado: (2020)

Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
por: Mühle, Christiane, et al.
Publicado: (2013)

Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls
por: Mühle, Christiane, et al.
Publicado: (2018)

The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic Fibrosis
por: Becker, Katrin Anne, et al.
Publicado: (2010)

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
por: Gulbins, Anne, et al.
Publicado: (2018)

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression
por: Mühle, Christiane, et al.
Publicado: (2019)

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants
por: Rhein, Cosima, et al.
Publicado: (2012)

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model
por: Péricat, D., et al.
Publicado: (2023)

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
por: Chami, Marwan, et al.
Publicado: (2017)

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls
por: Lea, Simon R, et al.
Publicado: (2016)

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase
por: Kornhuber, Johannes, et al.
Publicado: (2011)

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
por: Zeidan, Youssef H., et al.
Publicado: (2008)

Author Correction: A stochastic agent-based model of the SARS-CoV-2 epidemic in France
por: Hoertel, Nicolas, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6iidefvpek4je9scuurks08787