Cargando…

A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine

SIMPLE SUMMARY: Bovine mastitis is one of the most widespread cow diseases, which causes high economic losses. Local treatment using natural ingredients instead of the systematic use of antibiotics can decrease the development of antimicrobial resistance. The aim of the study was to determine the ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Kybartas, Modestas, Virgailis, Marius, Ruzauskas, Modestas, Klimienė, Irena, Šiugždinienė, Rita, Merkevičienė, Lina, Štreimikytė-Mockeliūnė, Žaneta, Mockeliūnas, Raimundas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458168/
https://www.ncbi.nlm.nih.gov/pubmed/37624297
http://dx.doi.org/10.3390/vetsci10080510
_version_ 1785097102672527360
author Kybartas, Modestas
Virgailis, Marius
Ruzauskas, Modestas
Klimienė, Irena
Šiugždinienė, Rita
Merkevičienė, Lina
Štreimikytė-Mockeliūnė, Žaneta
Mockeliūnas, Raimundas
author_facet Kybartas, Modestas
Virgailis, Marius
Ruzauskas, Modestas
Klimienė, Irena
Šiugždinienė, Rita
Merkevičienė, Lina
Štreimikytė-Mockeliūnė, Žaneta
Mockeliūnas, Raimundas
author_sort Kybartas, Modestas
collection PubMed
description SIMPLE SUMMARY: Bovine mastitis is one of the most widespread cow diseases, which causes high economic losses. Local treatment using natural ingredients instead of the systematic use of antibiotics can decrease the development of antimicrobial resistance. The aim of the study was to determine the physico-chemical properties, stability and antimicrobial effect of a newly formulated biocide for post-milking udder hygiene containing a thickener made from hydroxypropyl guar gum, an antiseptic chlorhexidine digluconate and teat skin-friendly components, including glycerol, Mentha Arvensis herbal oil and Aesculus hippocastanum extract. The product remains stable and homogenous for at least 12 months. The product also has good antimicrobial properties against the main mastitis pathogens, including Staphylococcus aureus, Streptococcus uberis, Escherichia coli, Candida albicans and Aspergillus niger. ABSTRACT: Despite much focus on mastitis as an endemic disease, clinical and subclinical mastitis remains an important problem for many herds. Reducing the usage of antibiotics for mastitis treatment allows the risks to be minimized related to the development of antimicrobial resistance and the excretion of antibiotics into the environment. The aim of the study was to determine the physico-chemical properties, stability and antimicrobial effect of a newly formulated biocide for post-milking udder hygiene containing a thickener made from hydroxypropyl guar gum, an antiseptic chlorhexidine digluconate and teat skin-friendly components including glycerol, Mentha Arvensis herbal oil and Aesculus hippocastanum extract. Hydroxypropyl guar gum was used as a thickener to provide the physical parameters and to retain the viscosity at 1438 mPa.s. The physical and chemical properties of the product, including the 12-month stability, were tested in long-term and accelerated stability studies. The product was effective against the primary mastitis pathogens, including Staphylococcus aureus, Streptococcus uberis, Escherichia coli, Candida albicans and Aspergillus niger.
format Online
Article
Text
id pubmed-10458168
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104581682023-08-27 A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine Kybartas, Modestas Virgailis, Marius Ruzauskas, Modestas Klimienė, Irena Šiugždinienė, Rita Merkevičienė, Lina Štreimikytė-Mockeliūnė, Žaneta Mockeliūnas, Raimundas Vet Sci Article SIMPLE SUMMARY: Bovine mastitis is one of the most widespread cow diseases, which causes high economic losses. Local treatment using natural ingredients instead of the systematic use of antibiotics can decrease the development of antimicrobial resistance. The aim of the study was to determine the physico-chemical properties, stability and antimicrobial effect of a newly formulated biocide for post-milking udder hygiene containing a thickener made from hydroxypropyl guar gum, an antiseptic chlorhexidine digluconate and teat skin-friendly components, including glycerol, Mentha Arvensis herbal oil and Aesculus hippocastanum extract. The product remains stable and homogenous for at least 12 months. The product also has good antimicrobial properties against the main mastitis pathogens, including Staphylococcus aureus, Streptococcus uberis, Escherichia coli, Candida albicans and Aspergillus niger. ABSTRACT: Despite much focus on mastitis as an endemic disease, clinical and subclinical mastitis remains an important problem for many herds. Reducing the usage of antibiotics for mastitis treatment allows the risks to be minimized related to the development of antimicrobial resistance and the excretion of antibiotics into the environment. The aim of the study was to determine the physico-chemical properties, stability and antimicrobial effect of a newly formulated biocide for post-milking udder hygiene containing a thickener made from hydroxypropyl guar gum, an antiseptic chlorhexidine digluconate and teat skin-friendly components including glycerol, Mentha Arvensis herbal oil and Aesculus hippocastanum extract. Hydroxypropyl guar gum was used as a thickener to provide the physical parameters and to retain the viscosity at 1438 mPa.s. The physical and chemical properties of the product, including the 12-month stability, were tested in long-term and accelerated stability studies. The product was effective against the primary mastitis pathogens, including Staphylococcus aureus, Streptococcus uberis, Escherichia coli, Candida albicans and Aspergillus niger. MDPI 2023-08-08 /pmc/articles/PMC10458168/ /pubmed/37624297 http://dx.doi.org/10.3390/vetsci10080510 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kybartas, Modestas
Virgailis, Marius
Ruzauskas, Modestas
Klimienė, Irena
Šiugždinienė, Rita
Merkevičienė, Lina
Štreimikytė-Mockeliūnė, Žaneta
Mockeliūnas, Raimundas
A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title_full A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title_fullStr A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title_full_unstemmed A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title_short A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine
title_sort study on the stability and antimicrobial efficacy of a newly modeled teat dip solution containing chlorhexidine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458168/
https://www.ncbi.nlm.nih.gov/pubmed/37624297
http://dx.doi.org/10.3390/vetsci10080510
work_keys_str_mv AT kybartasmodestas astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT virgailismarius astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT ruzauskasmodestas astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT klimieneirena astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT siugzdinienerita astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT merkevicienelina astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT streimikytemockeliunezaneta astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT mockeliunasraimundas astudyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT kybartasmodestas studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT virgailismarius studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT ruzauskasmodestas studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT klimieneirena studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT siugzdinienerita studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT merkevicienelina studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT streimikytemockeliunezaneta studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine
AT mockeliunasraimundas studyonthestabilityandantimicrobialefficacyofanewlymodeledteatdipsolutioncontainingchlorhexidine