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Material Transport Characteristics in Planetary Roller Melt Granulation

Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims fo...

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Detalles Bibliográficos
Autores principales: Lang, Tom, Bramböck, Andreas, Thommes, Markus, Bartsch, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458212/
https://www.ncbi.nlm.nih.gov/pubmed/37631253
http://dx.doi.org/10.3390/pharmaceutics15082039
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author Lang, Tom
Bramböck, Andreas
Thommes, Markus
Bartsch, Jens
author_facet Lang, Tom
Bramböck, Andreas
Thommes, Markus
Bartsch, Jens
author_sort Lang, Tom
collection PubMed
description Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing.
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spelling pubmed-104582122023-08-27 Material Transport Characteristics in Planetary Roller Melt Granulation Lang, Tom Bramböck, Andreas Thommes, Markus Bartsch, Jens Pharmaceutics Article Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing. MDPI 2023-07-28 /pmc/articles/PMC10458212/ /pubmed/37631253 http://dx.doi.org/10.3390/pharmaceutics15082039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lang, Tom
Bramböck, Andreas
Thommes, Markus
Bartsch, Jens
Material Transport Characteristics in Planetary Roller Melt Granulation
title Material Transport Characteristics in Planetary Roller Melt Granulation
title_full Material Transport Characteristics in Planetary Roller Melt Granulation
title_fullStr Material Transport Characteristics in Planetary Roller Melt Granulation
title_full_unstemmed Material Transport Characteristics in Planetary Roller Melt Granulation
title_short Material Transport Characteristics in Planetary Roller Melt Granulation
title_sort material transport characteristics in planetary roller melt granulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458212/
https://www.ncbi.nlm.nih.gov/pubmed/37631253
http://dx.doi.org/10.3390/pharmaceutics15082039
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