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New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies
Cancer is a complex multifactorial disease whose pathophysiology involves multiple metabolic pathways, including the ubiquitin–proteasome system, for which several proteasome inhibitors have already been approved for clinical use. However, the resistance to existing therapies and the occurrence of s...
Autores principales: | Guedes, Romina A., Grilo, Jorge H., Carvalho, Andreia N., Fernandes, Pedro M. P., Ressurreição, Ana S., Brito, Vanessa, Santos, Adriana O., Silvestre, Samuel, Gallerani, Eleonora, Gama, Maria João, Gavioli, Riccardo, Salvador, Jorge A. R., Guedes, Rita C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458307/ https://www.ncbi.nlm.nih.gov/pubmed/37631011 http://dx.doi.org/10.3390/ph16081096 |
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