Cargando…

Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease

Monoamine oxidase (MAO, EC 1.4.3.4) is responsible for the oxidative breakdown of both endogenous and exogenous amines and exists in MAO-A and MAO-B isomers. Eighteen indole-based phenylallylidene derivatives were synthesized via nucleophilic addition reactions comprising three sub-series, IHC, IHMC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manoharan, Amritha, Oh, Jong Min, Benny, Feba, Kumar, Sunil, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Shaker, Mohamed E., El-Sherbiny, Mohamed, Almohaimeed, Hailah M., Gahtori, Prashant, Kim, Hoon, Mathew, Bijo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458360/ https://www.ncbi.nlm.nih.gov/pubmed/37630420 http://dx.doi.org/10.3390/molecules28166167

Ejemplares similares

Isatin-based benzyloxybenzene derivatives as monoamine oxidase inhibitors with neuroprotective effect targeting neurogenerative disease treatment
por: Benny, Feba, et al.
Publicado: (2023)

Exploration of the Detailed Structure–Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors
por: Kumar, Sunil, et al.
Publicado: (2022)

Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
por: Jayan, Jayalakshmi, et al.
Publicado: (2023)

Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
por: Sudevan, Sachithra Thazhathuveedu, et al.
Publicado: (2022)

“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders
por: Manoharan, Amritha, et al.
Publicado: (2023)

Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation
por: Kumar, Sunil, et al.
Publicado: (2023)

Correction: Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation
por: Kumar, Sunil, et al.
Publicado: (2023)

A Concise Review of the Recent Structural Explorations of Chromones as MAO-B Inhibitors: Update from 2017 to 2023
por: Ipe, Reshma Susan, et al.
Publicado: (2023)

Navigating into the Chemical Space of Monoamine Oxidase Inhibitors by Artificial Intelligence and Cheminformatics Approach
por: Kumar, Sunil, et al.
Publicado: (2021)

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2022)

Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
por: Mathew, Bijo, et al.
Publicado: (2022)

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors
por: Sairam, Kalapatapu V.V.M., et al.
Publicado: (2007)

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
por: Sasidharan, Rani, et al.
Publicado: (2021)

Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions
por: Mathew, Bijo, et al.
Publicado: (2021)

Development of Halogenated Pyrazolines as Selective Monoamine Oxidase-B Inhibitors: Deciphering via Molecular Dynamics Approach
por: Nair, Aathira Sujathan, et al.
Publicado: (2021)

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors
por: Venkidath, Anusree, et al.
Publicado: (2021)

Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
por: Kumar, Sriramoju Bharath, et al.
Publicado: (2013)

Microwave-Assisted Synthesis of Cinnamyl Long Chain Aroma Esters
por: Worzakowska, Marta
Publicado: (2015)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

Simple and Efficient Microwave Assisted N-Alkylation of Isatin
por: Shmidt, María Sol, et al.
Publicado: (2008)

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
por: Oh, Jong Min, et al.
Publicado: (2020)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their N-benzylated derivatives for inhibition of the activity of monoamine oxidases
por: Perumal, Karuppaiah, et al.
Publicado: (2023)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation
por: Elsherbini, Dalia Mahmoud Abdelmonem, et al.
Publicado: (2022)

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease †
por: Purgatorio, Rosa, et al.
Publicado: (2020)

Catalytic enantioselective bromohydroxylation of cinnamyl alcohols
por: Li, Jing, et al.
Publicado: (2021)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Isatin derivatives as broad-spectrum antiviral agents: the current landscape
por: Elsaman, Tilal, et al.
Publicado: (2022)

Smoking Related Diseases: The Central Role of Monoamine Oxidase
por: Rendu, Francine, et al.
Publicado: (2011)

Androgen receptor and monoamine oxidase polymorphism in wild bonobos
por: Garai, Cintia, et al.
Publicado: (2014)

Inhibition of Monoamine Oxidase by Stilbenes from Rheum palmatum
por: Wei, Bo, et al.
Publicado: (2016)

Mitochondrial Monoamine Oxidase: Another Player in Pulmonary Hypertension?
por: Sommer, Natascha, et al.
Publicado: (2021)

Recent advances on the role of monoamine oxidases in cardiac pathophysiology
por: Kaludercic, Nina, et al.
Publicado: (2023)

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B
por: Chaurasiya, Narayan D., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lu2gnjoqbrh4c19qr1v4072740