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Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease

Monoamine oxidase (MAO, EC 1.4.3.4) is responsible for the oxidative breakdown of both endogenous and exogenous amines and exists in MAO-A and MAO-B isomers. Eighteen indole-based phenylallylidene derivatives were synthesized via nucleophilic addition reactions comprising three sub-series, IHC, IHMC...

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Detalles Bibliográficos
Autores principales:	Manoharan, Amritha, Oh, Jong Min, Benny, Feba, Kumar, Sunil, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Shaker, Mohamed E., El-Sherbiny, Mohamed, Almohaimeed, Hailah M., Gahtori, Prashant, Kim, Hoon, Mathew, Bijo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458360/ https://www.ncbi.nlm.nih.gov/pubmed/37630420 http://dx.doi.org/10.3390/molecules28166167

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