Cargando…
Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganes...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458488/ https://www.ncbi.nlm.nih.gov/pubmed/37623999 http://dx.doi.org/10.3390/pathogens12081039 |
_version_ | 1785097177874300928 |
---|---|
author | Łanocha-Arendarczyk, Natalia Kot, Karolina Baranowska-Bosiacka, Irena Kupnicka, Patrycja Przydalska, Dagmara Łanocha, Aleksandra Chlubek, Dariusz Wojciechowska-Koszko, Iwona Kosik-Bogacka, Danuta Izabela |
author_facet | Łanocha-Arendarczyk, Natalia Kot, Karolina Baranowska-Bosiacka, Irena Kupnicka, Patrycja Przydalska, Dagmara Łanocha, Aleksandra Chlubek, Dariusz Wojciechowska-Koszko, Iwona Kosik-Bogacka, Danuta Izabela |
author_sort | Łanocha-Arendarczyk, Natalia |
collection | PubMed |
description | Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganese (Mn), zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr), in the urine during acanthamoebiasis while considering the host’s immunological status. This is the first study to show an increase in urinary excretion of Ca, Mn, Cu, Fe, Na, and Cr, along with a decreased excretion of K, in immunocompetent mice 16 days post Acanthamoeba sp. infection. In the final phase of infection (24 dpi), there was a further decrease in urinary K excretion and a lower level of P in Acanthamoeba sp. infected immunocompetent hosts. During acanthamoebiasis in immunosuppressed hosts, increased excretion of Zn, Fe, and Cr was observed at the beginning of the infection, and increased Na excretion only at 16 days post Acanthamoeba sp. infection. Additionally, host immunosuppression affected the concentration of Fe, Cr, Zn, Cu, Mn, and Ca in urine. |
format | Online Article Text |
id | pubmed-10458488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104584882023-08-27 Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis Łanocha-Arendarczyk, Natalia Kot, Karolina Baranowska-Bosiacka, Irena Kupnicka, Patrycja Przydalska, Dagmara Łanocha, Aleksandra Chlubek, Dariusz Wojciechowska-Koszko, Iwona Kosik-Bogacka, Danuta Izabela Pathogens Article Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganese (Mn), zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr), in the urine during acanthamoebiasis while considering the host’s immunological status. This is the first study to show an increase in urinary excretion of Ca, Mn, Cu, Fe, Na, and Cr, along with a decreased excretion of K, in immunocompetent mice 16 days post Acanthamoeba sp. infection. In the final phase of infection (24 dpi), there was a further decrease in urinary K excretion and a lower level of P in Acanthamoeba sp. infected immunocompetent hosts. During acanthamoebiasis in immunosuppressed hosts, increased excretion of Zn, Fe, and Cr was observed at the beginning of the infection, and increased Na excretion only at 16 days post Acanthamoeba sp. infection. Additionally, host immunosuppression affected the concentration of Fe, Cr, Zn, Cu, Mn, and Ca in urine. MDPI 2023-08-14 /pmc/articles/PMC10458488/ /pubmed/37623999 http://dx.doi.org/10.3390/pathogens12081039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Łanocha-Arendarczyk, Natalia Kot, Karolina Baranowska-Bosiacka, Irena Kupnicka, Patrycja Przydalska, Dagmara Łanocha, Aleksandra Chlubek, Dariusz Wojciechowska-Koszko, Iwona Kosik-Bogacka, Danuta Izabela Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title | Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title_full | Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title_fullStr | Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title_full_unstemmed | Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title_short | Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis |
title_sort | macroelement and microelement levels in the urine in experimental acanthamoebiasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458488/ https://www.ncbi.nlm.nih.gov/pubmed/37623999 http://dx.doi.org/10.3390/pathogens12081039 |
work_keys_str_mv | AT łanochaarendarczyknatalia macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT kotkarolina macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT baranowskabosiackairena macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT kupnickapatrycja macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT przydalskadagmara macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT łanochaaleksandra macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT chlubekdariusz macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT wojciechowskakoszkoiwona macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis AT kosikbogackadanutaizabela macroelementandmicroelementlevelsintheurineinexperimentalacanthamoebiasis |