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Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis

Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganes...

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Autores principales: Łanocha-Arendarczyk, Natalia, Kot, Karolina, Baranowska-Bosiacka, Irena, Kupnicka, Patrycja, Przydalska, Dagmara, Łanocha, Aleksandra, Chlubek, Dariusz, Wojciechowska-Koszko, Iwona, Kosik-Bogacka, Danuta Izabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458488/
https://www.ncbi.nlm.nih.gov/pubmed/37623999
http://dx.doi.org/10.3390/pathogens12081039
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author Łanocha-Arendarczyk, Natalia
Kot, Karolina
Baranowska-Bosiacka, Irena
Kupnicka, Patrycja
Przydalska, Dagmara
Łanocha, Aleksandra
Chlubek, Dariusz
Wojciechowska-Koszko, Iwona
Kosik-Bogacka, Danuta Izabela
author_facet Łanocha-Arendarczyk, Natalia
Kot, Karolina
Baranowska-Bosiacka, Irena
Kupnicka, Patrycja
Przydalska, Dagmara
Łanocha, Aleksandra
Chlubek, Dariusz
Wojciechowska-Koszko, Iwona
Kosik-Bogacka, Danuta Izabela
author_sort Łanocha-Arendarczyk, Natalia
collection PubMed
description Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganese (Mn), zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr), in the urine during acanthamoebiasis while considering the host’s immunological status. This is the first study to show an increase in urinary excretion of Ca, Mn, Cu, Fe, Na, and Cr, along with a decreased excretion of K, in immunocompetent mice 16 days post Acanthamoeba sp. infection. In the final phase of infection (24 dpi), there was a further decrease in urinary K excretion and a lower level of P in Acanthamoeba sp. infected immunocompetent hosts. During acanthamoebiasis in immunosuppressed hosts, increased excretion of Zn, Fe, and Cr was observed at the beginning of the infection, and increased Na excretion only at 16 days post Acanthamoeba sp. infection. Additionally, host immunosuppression affected the concentration of Fe, Cr, Zn, Cu, Mn, and Ca in urine.
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spelling pubmed-104584882023-08-27 Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis Łanocha-Arendarczyk, Natalia Kot, Karolina Baranowska-Bosiacka, Irena Kupnicka, Patrycja Przydalska, Dagmara Łanocha, Aleksandra Chlubek, Dariusz Wojciechowska-Koszko, Iwona Kosik-Bogacka, Danuta Izabela Pathogens Article Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganese (Mn), zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr), in the urine during acanthamoebiasis while considering the host’s immunological status. This is the first study to show an increase in urinary excretion of Ca, Mn, Cu, Fe, Na, and Cr, along with a decreased excretion of K, in immunocompetent mice 16 days post Acanthamoeba sp. infection. In the final phase of infection (24 dpi), there was a further decrease in urinary K excretion and a lower level of P in Acanthamoeba sp. infected immunocompetent hosts. During acanthamoebiasis in immunosuppressed hosts, increased excretion of Zn, Fe, and Cr was observed at the beginning of the infection, and increased Na excretion only at 16 days post Acanthamoeba sp. infection. Additionally, host immunosuppression affected the concentration of Fe, Cr, Zn, Cu, Mn, and Ca in urine. MDPI 2023-08-14 /pmc/articles/PMC10458488/ /pubmed/37623999 http://dx.doi.org/10.3390/pathogens12081039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Łanocha-Arendarczyk, Natalia
Kot, Karolina
Baranowska-Bosiacka, Irena
Kupnicka, Patrycja
Przydalska, Dagmara
Łanocha, Aleksandra
Chlubek, Dariusz
Wojciechowska-Koszko, Iwona
Kosik-Bogacka, Danuta Izabela
Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title_full Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title_fullStr Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title_full_unstemmed Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title_short Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis
title_sort macroelement and microelement levels in the urine in experimental acanthamoebiasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458488/
https://www.ncbi.nlm.nih.gov/pubmed/37623999
http://dx.doi.org/10.3390/pathogens12081039
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