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The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China
The purpose of this study was to investigate possible influencing factors based on the distribution of the pertussis toxin (PT) and filamentous hemagglutinin (FHA) antibody levels in 0–14-year-old children in Jiangsu Province, China, and to analyze changes in IgG antibody levels after pertussis vacc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458620/ https://www.ncbi.nlm.nih.gov/pubmed/37631904 http://dx.doi.org/10.3390/vaccines11081336 |
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author | Wang, Wen Wang, Zhiguo Chen, Qiang Li, Mei Jia, Chengmei Xu, Yan Wu, Yun Sun, Xiang Sun, Hui |
author_facet | Wang, Wen Wang, Zhiguo Chen, Qiang Li, Mei Jia, Chengmei Xu, Yan Wu, Yun Sun, Xiang Sun, Hui |
author_sort | Wang, Wen |
collection | PubMed |
description | The purpose of this study was to investigate possible influencing factors based on the distribution of the pertussis toxin (PT) and filamentous hemagglutinin (FHA) antibody levels in 0–14-year-old children in Jiangsu Province, China, and to analyze changes in IgG antibody levels after pertussis vaccination in children over time via a restricted cubic spline (RCS)-fitted binary logistic regression model. We collected surveillance data on pertussis through the National Notifiable Disease Reporting System (NNDRS). Serum samples were collected, and PT IgG/FHA IgG antibody levels were determined via an enzyme-linked immunosorbent assay (ELISA). A binary logistic regression model was fitted with an RCS. Peak incidence occurred in children aged 0–1 years from 2007 to 2022, and a second peak emerged in children aged 5 years and older from 2018 onwards which shifted towards older age groups. The geometric mean concentrations (GMC) of the anti-PT IgG antibody and anti-FHA IgG antibody in 1129 patients were 15.13 (13.49–16.76) IU/mL and 22.99 (21.17–24.81) IU/mL, respectively. The seropositivity rates of the anti-PT IgG and anti-FHA IgG antibodies in the group receiving a full vaccination course (four doses) were significantly higher than those of other groups (24.6% vs. 43.3%). The RCS fitting model showed a non-linear relationship between the duration after immunization and the odds ratio (OR) of having PT-IgG and FHA-IgG antibody concentrations ≥20 IU/mL in children with documented immunization histories (1–4 doses) (P(overall) < 0. 001; P(nonlinear) ≤ 0.001). The children with histories of immunization demonstrated antibody levels that decreased to very low levels around 17 months after the last dose of the vaccine. Therefore, it is recommended that pertussis-containing vaccines be administered as booster immunizations for older children. |
format | Online Article Text |
id | pubmed-10458620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104586202023-08-27 The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China Wang, Wen Wang, Zhiguo Chen, Qiang Li, Mei Jia, Chengmei Xu, Yan Wu, Yun Sun, Xiang Sun, Hui Vaccines (Basel) Article The purpose of this study was to investigate possible influencing factors based on the distribution of the pertussis toxin (PT) and filamentous hemagglutinin (FHA) antibody levels in 0–14-year-old children in Jiangsu Province, China, and to analyze changes in IgG antibody levels after pertussis vaccination in children over time via a restricted cubic spline (RCS)-fitted binary logistic regression model. We collected surveillance data on pertussis through the National Notifiable Disease Reporting System (NNDRS). Serum samples were collected, and PT IgG/FHA IgG antibody levels were determined via an enzyme-linked immunosorbent assay (ELISA). A binary logistic regression model was fitted with an RCS. Peak incidence occurred in children aged 0–1 years from 2007 to 2022, and a second peak emerged in children aged 5 years and older from 2018 onwards which shifted towards older age groups. The geometric mean concentrations (GMC) of the anti-PT IgG antibody and anti-FHA IgG antibody in 1129 patients were 15.13 (13.49–16.76) IU/mL and 22.99 (21.17–24.81) IU/mL, respectively. The seropositivity rates of the anti-PT IgG and anti-FHA IgG antibodies in the group receiving a full vaccination course (four doses) were significantly higher than those of other groups (24.6% vs. 43.3%). The RCS fitting model showed a non-linear relationship between the duration after immunization and the odds ratio (OR) of having PT-IgG and FHA-IgG antibody concentrations ≥20 IU/mL in children with documented immunization histories (1–4 doses) (P(overall) < 0. 001; P(nonlinear) ≤ 0.001). The children with histories of immunization demonstrated antibody levels that decreased to very low levels around 17 months after the last dose of the vaccine. Therefore, it is recommended that pertussis-containing vaccines be administered as booster immunizations for older children. MDPI 2023-08-07 /pmc/articles/PMC10458620/ /pubmed/37631904 http://dx.doi.org/10.3390/vaccines11081336 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Wen Wang, Zhiguo Chen, Qiang Li, Mei Jia, Chengmei Xu, Yan Wu, Yun Sun, Xiang Sun, Hui The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title | The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title_full | The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title_fullStr | The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title_full_unstemmed | The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title_short | The Decay of Pertussis Antibodies in Children Aged 0–14 Years in Jiangsu Province, China |
title_sort | decay of pertussis antibodies in children aged 0–14 years in jiangsu province, china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458620/ https://www.ncbi.nlm.nih.gov/pubmed/37631904 http://dx.doi.org/10.3390/vaccines11081336 |
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