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Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Addition...

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Autores principales: Hetta, Helal F., Ramadan, Yasmin N., Al-Kadmy, Israa M. S., Ellah, Noura H. Abd, Shbibe, Lama, Battah, Basem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458664/
https://www.ncbi.nlm.nih.gov/pubmed/37623993
http://dx.doi.org/10.3390/pathogens12081033
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author Hetta, Helal F.
Ramadan, Yasmin N.
Al-Kadmy, Israa M. S.
Ellah, Noura H. Abd
Shbibe, Lama
Battah, Basem
author_facet Hetta, Helal F.
Ramadan, Yasmin N.
Al-Kadmy, Israa M. S.
Ellah, Noura H. Abd
Shbibe, Lama
Battah, Basem
author_sort Hetta, Helal F.
collection PubMed
description An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris.
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spelling pubmed-104586642023-08-27 Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections Hetta, Helal F. Ramadan, Yasmin N. Al-Kadmy, Israa M. S. Ellah, Noura H. Abd Shbibe, Lama Battah, Basem Pathogens Review An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris. MDPI 2023-08-13 /pmc/articles/PMC10458664/ /pubmed/37623993 http://dx.doi.org/10.3390/pathogens12081033 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hetta, Helal F.
Ramadan, Yasmin N.
Al-Kadmy, Israa M. S.
Ellah, Noura H. Abd
Shbibe, Lama
Battah, Basem
Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title_full Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title_fullStr Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title_full_unstemmed Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title_short Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
title_sort nanotechnology-based strategies to combat multidrug-resistant candida auris infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458664/
https://www.ncbi.nlm.nih.gov/pubmed/37623993
http://dx.doi.org/10.3390/pathogens12081033
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