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Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Addition...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458664/ https://www.ncbi.nlm.nih.gov/pubmed/37623993 http://dx.doi.org/10.3390/pathogens12081033 |
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author | Hetta, Helal F. Ramadan, Yasmin N. Al-Kadmy, Israa M. S. Ellah, Noura H. Abd Shbibe, Lama Battah, Basem |
author_facet | Hetta, Helal F. Ramadan, Yasmin N. Al-Kadmy, Israa M. S. Ellah, Noura H. Abd Shbibe, Lama Battah, Basem |
author_sort | Hetta, Helal F. |
collection | PubMed |
description | An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris. |
format | Online Article Text |
id | pubmed-10458664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104586642023-08-27 Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections Hetta, Helal F. Ramadan, Yasmin N. Al-Kadmy, Israa M. S. Ellah, Noura H. Abd Shbibe, Lama Battah, Basem Pathogens Review An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris. MDPI 2023-08-13 /pmc/articles/PMC10458664/ /pubmed/37623993 http://dx.doi.org/10.3390/pathogens12081033 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hetta, Helal F. Ramadan, Yasmin N. Al-Kadmy, Israa M. S. Ellah, Noura H. Abd Shbibe, Lama Battah, Basem Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title | Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title_full | Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title_fullStr | Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title_full_unstemmed | Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title_short | Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections |
title_sort | nanotechnology-based strategies to combat multidrug-resistant candida auris infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458664/ https://www.ncbi.nlm.nih.gov/pubmed/37623993 http://dx.doi.org/10.3390/pathogens12081033 |
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