Cargando…

Aberrant single-subject morphological cerebellar connectome in chronic insomnia

BACKGROUND: To systematically investigate the topological organisation of morphological networks of the cerebellum using structural MRI and examine their clinical relevance in chronic insomnia (CI). METHODS: One hundred and one patients with CI and 102 healthy controls (HCs) were recruited in this s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Yuqin, Fu, Shishun, Ye, Xi, Yang, Yuping, Yin, Yi, Xu, Guang, Liu, Mengchen, Jiang, Guihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458694/
https://www.ncbi.nlm.nih.gov/pubmed/37603949
http://dx.doi.org/10.1016/j.nicl.2023.103492
_version_ 1785097227238113280
author Ma, Yuqin
Fu, Shishun
Ye, Xi
Yang, Yuping
Yin, Yi
Xu, Guang
Liu, Mengchen
Jiang, Guihua
author_facet Ma, Yuqin
Fu, Shishun
Ye, Xi
Yang, Yuping
Yin, Yi
Xu, Guang
Liu, Mengchen
Jiang, Guihua
author_sort Ma, Yuqin
collection PubMed
description BACKGROUND: To systematically investigate the topological organisation of morphological networks of the cerebellum using structural MRI and examine their clinical relevance in chronic insomnia (CI). METHODS: One hundred and one patients with CI and 102 healthy controls (HCs) were recruited in this study. Individual morphological networks of the cerebellum were constructed based on regional grey matter volume, and topologically characterised using weighted graph theory-based network approaches. Between-group comparisons were performed using permutation tests, and Spearman’s correlation was used to examine the relationships between topological alterations and clinical variables. RESULTS: Compared with HCs, patients with CI exhibited a lower normalised clustering coefficient. Locally, CI patients exhibited lower nodal efficiency in the cerebellar lobule VIIb and vermis regions, but higher nodal efficiency in the right cerebellar lobule VIIIa regions. No correlations were observed between network alterations and clinical variables. CONCLUSIONS: Individual morphological network analysis provides a new strategy for investigating cerebellar morphometric changes in CI, and our findings may have important implications in establishing diagnostic and categorical biomarkers.
format Online
Article
Text
id pubmed-10458694
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-104586942023-08-27 Aberrant single-subject morphological cerebellar connectome in chronic insomnia Ma, Yuqin Fu, Shishun Ye, Xi Yang, Yuping Yin, Yi Xu, Guang Liu, Mengchen Jiang, Guihua Neuroimage Clin Regular Article BACKGROUND: To systematically investigate the topological organisation of morphological networks of the cerebellum using structural MRI and examine their clinical relevance in chronic insomnia (CI). METHODS: One hundred and one patients with CI and 102 healthy controls (HCs) were recruited in this study. Individual morphological networks of the cerebellum were constructed based on regional grey matter volume, and topologically characterised using weighted graph theory-based network approaches. Between-group comparisons were performed using permutation tests, and Spearman’s correlation was used to examine the relationships between topological alterations and clinical variables. RESULTS: Compared with HCs, patients with CI exhibited a lower normalised clustering coefficient. Locally, CI patients exhibited lower nodal efficiency in the cerebellar lobule VIIb and vermis regions, but higher nodal efficiency in the right cerebellar lobule VIIIa regions. No correlations were observed between network alterations and clinical variables. CONCLUSIONS: Individual morphological network analysis provides a new strategy for investigating cerebellar morphometric changes in CI, and our findings may have important implications in establishing diagnostic and categorical biomarkers. Elsevier 2023-08-16 /pmc/articles/PMC10458694/ /pubmed/37603949 http://dx.doi.org/10.1016/j.nicl.2023.103492 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Ma, Yuqin
Fu, Shishun
Ye, Xi
Yang, Yuping
Yin, Yi
Xu, Guang
Liu, Mengchen
Jiang, Guihua
Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title_full Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title_fullStr Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title_full_unstemmed Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title_short Aberrant single-subject morphological cerebellar connectome in chronic insomnia
title_sort aberrant single-subject morphological cerebellar connectome in chronic insomnia
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458694/
https://www.ncbi.nlm.nih.gov/pubmed/37603949
http://dx.doi.org/10.1016/j.nicl.2023.103492
work_keys_str_mv AT mayuqin aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT fushishun aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT yexi aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT yangyuping aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT yinyi aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT xuguang aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT liumengchen aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia
AT jiangguihua aberrantsinglesubjectmorphologicalcerebellarconnectomeinchronicinsomnia