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The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.
Hydrogen sulfide (H(2)S) signaling and H(2)S-prodrugs maintain redox balance in gastrointestinal (GI) tract. Predominant effect of any H(2)S-donor is mitochondrial. Non-targeted H(2)S-moieties were shown to decrease the non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrotoxicity but in hig...
Autores principales: | Magierowska, Katarzyna, Wójcik-Grzybek, Dagmara, Korbut, Edyta, Bakalarz, Dominik, Ginter, Grzegorz, Danielak, Aleksandra, Kwiecień, Sławomir, Chmura, Anna, Torregrossa, Roberta, Whiteman, Matthew, Magierowski, Marcin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458696/ https://www.ncbi.nlm.nih.gov/pubmed/37597422 http://dx.doi.org/10.1016/j.redox.2023.102847 |
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