Monitoring Both Extended and Tryptic Forms of Stable Isotope-Labeled Standard Peptides Provides an Internal Quality Control of Proteolytic Digestion in Targeted Mass Spectrometry-Based Assays

Targeted mass spectrometry (MS)-based proteomic assays, such as multiplexed multiple reaction monitoring (MRM)-MS assays, enable sensitive and specific quantification of proteotypic peptides as stoichiometric surrogates for proteins. Efforts are underway to expand the use of MRM-MS assays in clinica...

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Detalles Bibliográficos
Autores principales: Lundeen, Rachel A., Kennedy, Jacob J., Murillo, Oscar D., Ivey, Richard G., Zhao, Lei, Schoenherr, Regine M., Hoofnagle, Andrew N., Wang, Pei, Whiteaker, Jeffrey R., Paulovich, Amanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458721/
https://www.ncbi.nlm.nih.gov/pubmed/37478973
http://dx.doi.org/10.1016/j.mcpro.2023.100621

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