A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities

Eukaryotic protein kinases (EPKs) adopt an active conformation following phosphorylation of a particular activation loop residue. Most EPKs spontaneously autophosphorylate this residue. While structure–function relationships of the active conformation are essentially understood, those of the “prone-...

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Detalles Bibliográficos
Autores principales: Soudah, Nadine, Baskin, Alexey, Smorodinsky-Atias, Karin, Beenstock, Jonah, Ganon, Yifat, Hayouka, Ruchama, Aboraya, Mohammed, Livnah, Oded, Ilouz, Ronit, Engelberg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458722/
https://www.ncbi.nlm.nih.gov/pubmed/37474104
http://dx.doi.org/10.1016/j.jbc.2023.105072

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