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Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants

Given the limitations of conventional invasive vaccines, such as the requirement for a cold chain system and trained personnel, needle-based injuries, and limited immunogenicity, non-invasive vaccines have gained significant attention. Although numerous approaches for formulating and administrating...

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Detalles Bibliográficos
Autores principales: Han, Sumin, Lee, Panjae, Choi, Hyo-Jick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458847/
https://www.ncbi.nlm.nih.gov/pubmed/37631328
http://dx.doi.org/10.3390/pharmaceutics15082114
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author Han, Sumin
Lee, Panjae
Choi, Hyo-Jick
author_facet Han, Sumin
Lee, Panjae
Choi, Hyo-Jick
author_sort Han, Sumin
collection PubMed
description Given the limitations of conventional invasive vaccines, such as the requirement for a cold chain system and trained personnel, needle-based injuries, and limited immunogenicity, non-invasive vaccines have gained significant attention. Although numerous approaches for formulating and administrating non-invasive vaccines have emerged, each of them faces its own challenges associated with vaccine bioavailability, toxicity, and other issues. To overcome such limitations, researchers have created novel supplementary materials and delivery systems. The goal of this review article is to provide vaccine formulation researchers with the most up-to-date information on vaccine formulation and the immunological mechanisms available, to identify the technical challenges associated with the commercialization of non-invasive vaccines, and to guide future research and development efforts.
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spelling pubmed-104588472023-08-27 Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants Han, Sumin Lee, Panjae Choi, Hyo-Jick Pharmaceutics Review Given the limitations of conventional invasive vaccines, such as the requirement for a cold chain system and trained personnel, needle-based injuries, and limited immunogenicity, non-invasive vaccines have gained significant attention. Although numerous approaches for formulating and administrating non-invasive vaccines have emerged, each of them faces its own challenges associated with vaccine bioavailability, toxicity, and other issues. To overcome such limitations, researchers have created novel supplementary materials and delivery systems. The goal of this review article is to provide vaccine formulation researchers with the most up-to-date information on vaccine formulation and the immunological mechanisms available, to identify the technical challenges associated with the commercialization of non-invasive vaccines, and to guide future research and development efforts. MDPI 2023-08-09 /pmc/articles/PMC10458847/ /pubmed/37631328 http://dx.doi.org/10.3390/pharmaceutics15082114 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Han, Sumin
Lee, Panjae
Choi, Hyo-Jick
Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title_full Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title_fullStr Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title_full_unstemmed Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title_short Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants
title_sort non-invasive vaccines: challenges in formulation and vaccine adjuvants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458847/
https://www.ncbi.nlm.nih.gov/pubmed/37631328
http://dx.doi.org/10.3390/pharmaceutics15082114
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