Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine

Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD...

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Detalles Bibliográficos
Autores principales: Mahant, Aakash Mahant, Gromisch, Matthew S., Kravets, Leah, Burn Aschner, Clare, Herold, Betsy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458853/
https://www.ncbi.nlm.nih.gov/pubmed/37631930
http://dx.doi.org/10.3390/vaccines11081362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458853/
https://www.ncbi.nlm.nih.gov/pubmed/37631930
http://dx.doi.org/10.3390/vaccines11081362

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