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Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine

Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD...

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Detalles Bibliográficos
Autores principales:	Mahant, Aakash Mahant, Gromisch, Matthew S., Kravets, Leah, Burn Aschner, Clare, Herold, Betsy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458853/ https://www.ncbi.nlm.nih.gov/pubmed/37631930 http://dx.doi.org/10.3390/vaccines11081362

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