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Update on the Phylodynamic and Genetic Variability of Marburg Virus

The COVID-19 pandemic has not only strained healthcare systems in Africa but has also intensified the impact of emerging and re-emerging diseases. Specifically in Equatorial Guinea, mirroring the situation in other African countries, unique zoonotic outbreaks have occurred during this challenging pe...

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Autores principales: Scarpa, Fabio, Bazzani, Liliana, Giovanetti, Marta, Ciccozzi, Alessandra, Benedetti, Francesca, Zella, Davide, Sanna, Daria, Casu, Marco, Borsetti, Alessandra, Cella, Eleonora, Pascarella, Stefano, Maruotti, Antonello, Ciccozzi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458864/
https://www.ncbi.nlm.nih.gov/pubmed/37632063
http://dx.doi.org/10.3390/v15081721
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author Scarpa, Fabio
Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
author_facet Scarpa, Fabio
Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
author_sort Scarpa, Fabio
collection PubMed
description The COVID-19 pandemic has not only strained healthcare systems in Africa but has also intensified the impact of emerging and re-emerging diseases. Specifically in Equatorial Guinea, mirroring the situation in other African countries, unique zoonotic outbreaks have occurred during this challenging period. One notable resurgence is Marburg virus disease (MVD), which has further burdened the already fragile healthcare system. The re-emergence of the Marburg virus amid the COVID-19 pandemic is believed to stem from a probable zoonotic spill-over, although the precise transmission routes remain uncertain. Given the gravity of the situation, addressing the existing challenges is paramount. Though the genome sequences from the current outbreak were not available for this study, we analyzed all the available whole genome sequences of this re-emerging pathogen to advocate for a shift towards active surveillance. This is essential to ensure the successful containment of any potential Marburg virus outbreak in Equatorial Guinea and the wider African context. This study, which presents an update on the phylodynamics and the genetic variability of MARV, further confirmed the existence of at least two distinct patterns of viral spread. One pattern demonstrates a slower but continuous and recurring virus circulation, while the other exhibits a faster yet limited and episodic spread. These results highlight the critical need to strengthen genomic surveillance in the region to effectively curb the pathogen’s dissemination. Moreover, the study emphasizes the importance of prompt alert management, comprehensive case investigation and analysis, contact tracing, and active case searching. These steps are vital to support the healthcare system’s response to this emerging health crisis. By implementing these strategies, we can better arm ourselves against the challenges posed by the resurgence of the Marburg virus and other infectious diseases.
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spelling pubmed-104588642023-08-27 Update on the Phylodynamic and Genetic Variability of Marburg Virus Scarpa, Fabio Bazzani, Liliana Giovanetti, Marta Ciccozzi, Alessandra Benedetti, Francesca Zella, Davide Sanna, Daria Casu, Marco Borsetti, Alessandra Cella, Eleonora Pascarella, Stefano Maruotti, Antonello Ciccozzi, Massimo Viruses Article The COVID-19 pandemic has not only strained healthcare systems in Africa but has also intensified the impact of emerging and re-emerging diseases. Specifically in Equatorial Guinea, mirroring the situation in other African countries, unique zoonotic outbreaks have occurred during this challenging period. One notable resurgence is Marburg virus disease (MVD), which has further burdened the already fragile healthcare system. The re-emergence of the Marburg virus amid the COVID-19 pandemic is believed to stem from a probable zoonotic spill-over, although the precise transmission routes remain uncertain. Given the gravity of the situation, addressing the existing challenges is paramount. Though the genome sequences from the current outbreak were not available for this study, we analyzed all the available whole genome sequences of this re-emerging pathogen to advocate for a shift towards active surveillance. This is essential to ensure the successful containment of any potential Marburg virus outbreak in Equatorial Guinea and the wider African context. This study, which presents an update on the phylodynamics and the genetic variability of MARV, further confirmed the existence of at least two distinct patterns of viral spread. One pattern demonstrates a slower but continuous and recurring virus circulation, while the other exhibits a faster yet limited and episodic spread. These results highlight the critical need to strengthen genomic surveillance in the region to effectively curb the pathogen’s dissemination. Moreover, the study emphasizes the importance of prompt alert management, comprehensive case investigation and analysis, contact tracing, and active case searching. These steps are vital to support the healthcare system’s response to this emerging health crisis. By implementing these strategies, we can better arm ourselves against the challenges posed by the resurgence of the Marburg virus and other infectious diseases. MDPI 2023-08-11 /pmc/articles/PMC10458864/ /pubmed/37632063 http://dx.doi.org/10.3390/v15081721 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scarpa, Fabio
Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
Update on the Phylodynamic and Genetic Variability of Marburg Virus
title Update on the Phylodynamic and Genetic Variability of Marburg Virus
title_full Update on the Phylodynamic and Genetic Variability of Marburg Virus
title_fullStr Update on the Phylodynamic and Genetic Variability of Marburg Virus
title_full_unstemmed Update on the Phylodynamic and Genetic Variability of Marburg Virus
title_short Update on the Phylodynamic and Genetic Variability of Marburg Virus
title_sort update on the phylodynamic and genetic variability of marburg virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458864/
https://www.ncbi.nlm.nih.gov/pubmed/37632063
http://dx.doi.org/10.3390/v15081721
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