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Cocaine Effects on Reproductive Behavior and Fertility: An Overview

SIMPLE SUMMARY: Cocaine, a widely used drug, can influence sexual behavior. It has been shown, especially in mammals, that cocaine can cause various disorders of sexual activity and gonadal dysfunction in both sexes. Cocaine has been found to alter the cell cycle, alter the meiotic spindle, induce a...

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Autores principales: Rosati, Luigi, Chianese, Teresa, Mileo, Aldo, De Falco, Maria, Capaldo, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458869/
https://www.ncbi.nlm.nih.gov/pubmed/37624271
http://dx.doi.org/10.3390/vetsci10080484
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author Rosati, Luigi
Chianese, Teresa
Mileo, Aldo
De Falco, Maria
Capaldo, Anna
author_facet Rosati, Luigi
Chianese, Teresa
Mileo, Aldo
De Falco, Maria
Capaldo, Anna
author_sort Rosati, Luigi
collection PubMed
description SIMPLE SUMMARY: Cocaine, a widely used drug, can influence sexual behavior. It has been shown, especially in mammals, that cocaine can cause various disorders of sexual activity and gonadal dysfunction in both sexes. Cocaine has been found to alter the cell cycle, alter the meiotic spindle, induce apoptosis, and alter sperm motility. This review provides an overview of the main effects of cocaine on spermatogenesis and oogenesis, laying the groundwork for future investigations into the molecular mechanisms underlying the interaction of cocaine and its metabolites with germ cells. ABSTRACT: Cocaine is one of the most widely used drugs that, due to its molecular properties, causes various behavioral alterations, including sexual behavior. In vivo and in vitro studies conducted mainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has been shown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug alters the formation of the meiotic spindle as well as may obstruct the ovulation mechanism of mature oocytes. The data provided in this review, in addition to reviewing the current literature on the main effects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully provide a basic overview that may help and support further future studies on the molecular interaction of cocaine and its metabolites with germ cells.
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spelling pubmed-104588692023-08-27 Cocaine Effects on Reproductive Behavior and Fertility: An Overview Rosati, Luigi Chianese, Teresa Mileo, Aldo De Falco, Maria Capaldo, Anna Vet Sci Review SIMPLE SUMMARY: Cocaine, a widely used drug, can influence sexual behavior. It has been shown, especially in mammals, that cocaine can cause various disorders of sexual activity and gonadal dysfunction in both sexes. Cocaine has been found to alter the cell cycle, alter the meiotic spindle, induce apoptosis, and alter sperm motility. This review provides an overview of the main effects of cocaine on spermatogenesis and oogenesis, laying the groundwork for future investigations into the molecular mechanisms underlying the interaction of cocaine and its metabolites with germ cells. ABSTRACT: Cocaine is one of the most widely used drugs that, due to its molecular properties, causes various behavioral alterations, including sexual behavior. In vivo and in vitro studies conducted mainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has been shown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug alters the formation of the meiotic spindle as well as may obstruct the ovulation mechanism of mature oocytes. The data provided in this review, in addition to reviewing the current literature on the main effects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully provide a basic overview that may help and support further future studies on the molecular interaction of cocaine and its metabolites with germ cells. MDPI 2023-07-25 /pmc/articles/PMC10458869/ /pubmed/37624271 http://dx.doi.org/10.3390/vetsci10080484 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rosati, Luigi
Chianese, Teresa
Mileo, Aldo
De Falco, Maria
Capaldo, Anna
Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title_full Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title_fullStr Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title_full_unstemmed Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title_short Cocaine Effects on Reproductive Behavior and Fertility: An Overview
title_sort cocaine effects on reproductive behavior and fertility: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458869/
https://www.ncbi.nlm.nih.gov/pubmed/37624271
http://dx.doi.org/10.3390/vetsci10080484
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