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Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens. However, its extremely high hemolytic activity and cytotoxicity...

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Detalles Bibliográficos
Autores principales:	Bolosov, Ilia A., Panteleev, Pavel V., Sychev, Sergei V., Khokhlova, Veronika A., Safronova, Victoria N., Toropygin, Ilia Yu., Kombarova, Tatiana I., Korobova, Olga V., Pereskokova, Eugenia S., Borzilov, Alexander I., Ovchinnikova, Tatiana V., Balandin, Sergey V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458893/ https://www.ncbi.nlm.nih.gov/pubmed/37631261 http://dx.doi.org/10.3390/pharmaceutics15082047

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