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A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy

(1) Background: Human keratinocytes and murine skin express various cytochrome P450 enzymes. These include cytochrome P450 3A4, which may participate in the metabolism of cytochrome P450 3A4 substrate drugs. Desoximetasone, a topical corticosteroid and cytochrome P450 3A4 substrate, is used to treat...

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Detalles Bibliográficos
Autores principales:	Guo, Jiun-Wen, Cheng, Yu-Pin, Lim, Cherng-Jyr, Liu, Chih-Yi, Jee, Shiou-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458942/ https://www.ncbi.nlm.nih.gov/pubmed/37631230 http://dx.doi.org/10.3390/pharmaceutics15082016

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