Cargando…

Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD)—a new definition for non-alcoholic fatty liver disease—reflects the impact of metabolic abnormalities on liver function. We assessed the diagnostic accuracy of biomarker-based scores for prediction of MAFLD in apparently heal...

Descripción completa

Detalles Bibliográficos
Autores principales: Bergmann, Katarzyna, Stefanska, Anna, Krintus, Magdalena, Szternel, Lukasz, Bilinski, Wojciech J., Paradowski, Przemyslaw T., Sypniewska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458960/
https://www.ncbi.nlm.nih.gov/pubmed/37630857
http://dx.doi.org/10.3390/nu15163667
_version_ 1785097292734267392
author Bergmann, Katarzyna
Stefanska, Anna
Krintus, Magdalena
Szternel, Lukasz
Bilinski, Wojciech J.
Paradowski, Przemyslaw T.
Sypniewska, Grazyna
author_facet Bergmann, Katarzyna
Stefanska, Anna
Krintus, Magdalena
Szternel, Lukasz
Bilinski, Wojciech J.
Paradowski, Przemyslaw T.
Sypniewska, Grazyna
author_sort Bergmann, Katarzyna
collection PubMed
description Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD)—a new definition for non-alcoholic fatty liver disease—reflects the impact of metabolic abnormalities on liver function. We assessed the diagnostic accuracy of biomarker-based scores for prediction of MAFLD in apparently healthy children. Methods: This study included 144 children aged 9–11. MAFLD was recognized in 14 girls and 29 boys. Anthropometric indices, glycemia, insulin resistance, lipid profile, enzymes (ALT, AST, GGT, ALP), CRP, N-terminal propeptide of type I procollagen (P1NP) and collagen type I C-telopeptide (CTX-1) levels were measured. Fatty liver and hepatic steatosis index (FLI, HSI) and potential indicators of liver fibrogenesis: P1NP/ALP, P1NP/ALPxALT, P1NP/ALPxCRP were calculated. Results: P1NP/ALPxALT and P1NP/ALPxCRP were significantly higher in subjects with MAFLD. FLI was a good, significant predictor of MAFLD occurrence, regardless of sex. In boys, P1NP/ALPxCRP was a comparable predictor as CRP (OR 1.14 vs. 1.17; p < 0.001). P1NP/ALPxCRP had better discrimination capability in boys (AUC = 0.79; p < 0.001). However, the use of this algorithm did not improve discriminatory power in comparison to CRP (AUC = 0.81; p < 0.001), but gave a better sensitivity for MAFLD prediction (86% vs. 59%). Conclusions: We suggest that P1NP/ALPXCRP is a reliable tool for MAFLD prediction in routine pediatric practice.
format Online
Article
Text
id pubmed-10458960
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104589602023-08-27 Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children Bergmann, Katarzyna Stefanska, Anna Krintus, Magdalena Szternel, Lukasz Bilinski, Wojciech J. Paradowski, Przemyslaw T. Sypniewska, Grazyna Nutrients Article Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD)—a new definition for non-alcoholic fatty liver disease—reflects the impact of metabolic abnormalities on liver function. We assessed the diagnostic accuracy of biomarker-based scores for prediction of MAFLD in apparently healthy children. Methods: This study included 144 children aged 9–11. MAFLD was recognized in 14 girls and 29 boys. Anthropometric indices, glycemia, insulin resistance, lipid profile, enzymes (ALT, AST, GGT, ALP), CRP, N-terminal propeptide of type I procollagen (P1NP) and collagen type I C-telopeptide (CTX-1) levels were measured. Fatty liver and hepatic steatosis index (FLI, HSI) and potential indicators of liver fibrogenesis: P1NP/ALP, P1NP/ALPxALT, P1NP/ALPxCRP were calculated. Results: P1NP/ALPxALT and P1NP/ALPxCRP were significantly higher in subjects with MAFLD. FLI was a good, significant predictor of MAFLD occurrence, regardless of sex. In boys, P1NP/ALPxCRP was a comparable predictor as CRP (OR 1.14 vs. 1.17; p < 0.001). P1NP/ALPxCRP had better discrimination capability in boys (AUC = 0.79; p < 0.001). However, the use of this algorithm did not improve discriminatory power in comparison to CRP (AUC = 0.81; p < 0.001), but gave a better sensitivity for MAFLD prediction (86% vs. 59%). Conclusions: We suggest that P1NP/ALPXCRP is a reliable tool for MAFLD prediction in routine pediatric practice. MDPI 2023-08-21 /pmc/articles/PMC10458960/ /pubmed/37630857 http://dx.doi.org/10.3390/nu15163667 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bergmann, Katarzyna
Stefanska, Anna
Krintus, Magdalena
Szternel, Lukasz
Bilinski, Wojciech J.
Paradowski, Przemyslaw T.
Sypniewska, Grazyna
Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title_full Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title_fullStr Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title_full_unstemmed Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title_short Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children
title_sort diagnostic performance of biomarker-based scores as predictors of metabolic dysfunction-associated fatty liver disease risk in healthy children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458960/
https://www.ncbi.nlm.nih.gov/pubmed/37630857
http://dx.doi.org/10.3390/nu15163667
work_keys_str_mv AT bergmannkatarzyna diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT stefanskaanna diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT krintusmagdalena diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT szternellukasz diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT bilinskiwojciechj diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT paradowskiprzemyslawt diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren
AT sypniewskagrazyna diagnosticperformanceofbiomarkerbasedscoresaspredictorsofmetabolicdysfunctionassociatedfattyliverdiseaseriskinhealthychildren