Cargando…
A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to con...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459152/ https://www.ncbi.nlm.nih.gov/pubmed/37630749 http://dx.doi.org/10.3390/nu15163559 |
_version_ | 1785097340999172096 |
---|---|
author | Mysore Saiprasad, Sindusha Moreno, Olivia Grace Savaiano, Dennis A. |
author_facet | Mysore Saiprasad, Sindusha Moreno, Olivia Grace Savaiano, Dennis A. |
author_sort | Mysore Saiprasad, Sindusha |
collection | PubMed |
description | Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to consumption of Bifidobacterium, GOS, or both. A total of 152 studies on Bifidobacterium and GOS or both were published between 1983 and 2022. Out of the 152 studies, 20 were human clinical trials conducted in lactose intolerant subjects; 8 studies were conducted with Bifidobacterium supplementation and 3 studies involved GOS supplementation. Five studies reported favorable outcomes of Bifidobacterium supplementation in managing lactose intolerance (LI). Similarly, three studies reported favorable outcomes with GOS supplementation. The other three studies reported neutral outcomes. In conclusion, most studies reported a favorable effect of Bifidobacterium and GOS on managing the symptoms of LI. No study has examined the effects of combined supplementation with Bifidobacterium and GOS in lactose intolerant subjects. Future research could examine if co-supplementation with Bifidobacterium and GOS is a more effective strategy to reduce the dairy discomfort in LI individuals. |
format | Online Article Text |
id | pubmed-10459152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104591522023-08-27 A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides Mysore Saiprasad, Sindusha Moreno, Olivia Grace Savaiano, Dennis A. Nutrients Review Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to consumption of Bifidobacterium, GOS, or both. A total of 152 studies on Bifidobacterium and GOS or both were published between 1983 and 2022. Out of the 152 studies, 20 were human clinical trials conducted in lactose intolerant subjects; 8 studies were conducted with Bifidobacterium supplementation and 3 studies involved GOS supplementation. Five studies reported favorable outcomes of Bifidobacterium supplementation in managing lactose intolerance (LI). Similarly, three studies reported favorable outcomes with GOS supplementation. The other three studies reported neutral outcomes. In conclusion, most studies reported a favorable effect of Bifidobacterium and GOS on managing the symptoms of LI. No study has examined the effects of combined supplementation with Bifidobacterium and GOS in lactose intolerant subjects. Future research could examine if co-supplementation with Bifidobacterium and GOS is a more effective strategy to reduce the dairy discomfort in LI individuals. MDPI 2023-08-12 /pmc/articles/PMC10459152/ /pubmed/37630749 http://dx.doi.org/10.3390/nu15163559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mysore Saiprasad, Sindusha Moreno, Olivia Grace Savaiano, Dennis A. A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title | A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title_full | A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title_fullStr | A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title_full_unstemmed | A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title_short | A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides |
title_sort | narrative review of human clinical trials to improve lactose digestion and tolerance by feeding bifidobacteria or galacto-oligosacharides |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459152/ https://www.ncbi.nlm.nih.gov/pubmed/37630749 http://dx.doi.org/10.3390/nu15163559 |
work_keys_str_mv | AT mysoresaiprasadsindusha anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides AT morenooliviagrace anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides AT savaianodennisa anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides AT mysoresaiprasadsindusha narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides AT morenooliviagrace narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides AT savaianodennisa narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides |