Cargando…

A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides

Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to con...

Descripción completa

Detalles Bibliográficos
Autores principales: Mysore Saiprasad, Sindusha, Moreno, Olivia Grace, Savaiano, Dennis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459152/
https://www.ncbi.nlm.nih.gov/pubmed/37630749
http://dx.doi.org/10.3390/nu15163559
_version_ 1785097340999172096
author Mysore Saiprasad, Sindusha
Moreno, Olivia Grace
Savaiano, Dennis A.
author_facet Mysore Saiprasad, Sindusha
Moreno, Olivia Grace
Savaiano, Dennis A.
author_sort Mysore Saiprasad, Sindusha
collection PubMed
description Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to consumption of Bifidobacterium, GOS, or both. A total of 152 studies on Bifidobacterium and GOS or both were published between 1983 and 2022. Out of the 152 studies, 20 were human clinical trials conducted in lactose intolerant subjects; 8 studies were conducted with Bifidobacterium supplementation and 3 studies involved GOS supplementation. Five studies reported favorable outcomes of Bifidobacterium supplementation in managing lactose intolerance (LI). Similarly, three studies reported favorable outcomes with GOS supplementation. The other three studies reported neutral outcomes. In conclusion, most studies reported a favorable effect of Bifidobacterium and GOS on managing the symptoms of LI. No study has examined the effects of combined supplementation with Bifidobacterium and GOS in lactose intolerant subjects. Future research could examine if co-supplementation with Bifidobacterium and GOS is a more effective strategy to reduce the dairy discomfort in LI individuals.
format Online
Article
Text
id pubmed-10459152
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104591522023-08-27 A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides Mysore Saiprasad, Sindusha Moreno, Olivia Grace Savaiano, Dennis A. Nutrients Review Supplementation with the probiotic Bifidobacterium and prebiotic galacto-oligosaccharides (GOS) could improve gut health and benefit lactose intolerant individuals. A narrative review was conducted to identify human clinical trials that evaluated lactose digestion and/or tolerance in response to consumption of Bifidobacterium, GOS, or both. A total of 152 studies on Bifidobacterium and GOS or both were published between 1983 and 2022. Out of the 152 studies, 20 were human clinical trials conducted in lactose intolerant subjects; 8 studies were conducted with Bifidobacterium supplementation and 3 studies involved GOS supplementation. Five studies reported favorable outcomes of Bifidobacterium supplementation in managing lactose intolerance (LI). Similarly, three studies reported favorable outcomes with GOS supplementation. The other three studies reported neutral outcomes. In conclusion, most studies reported a favorable effect of Bifidobacterium and GOS on managing the symptoms of LI. No study has examined the effects of combined supplementation with Bifidobacterium and GOS in lactose intolerant subjects. Future research could examine if co-supplementation with Bifidobacterium and GOS is a more effective strategy to reduce the dairy discomfort in LI individuals. MDPI 2023-08-12 /pmc/articles/PMC10459152/ /pubmed/37630749 http://dx.doi.org/10.3390/nu15163559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mysore Saiprasad, Sindusha
Moreno, Olivia Grace
Savaiano, Dennis A.
A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title_full A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title_fullStr A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title_full_unstemmed A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title_short A Narrative Review of Human Clinical Trials to Improve Lactose Digestion and Tolerance by Feeding Bifidobacteria or Galacto-Oligosacharides
title_sort narrative review of human clinical trials to improve lactose digestion and tolerance by feeding bifidobacteria or galacto-oligosacharides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459152/
https://www.ncbi.nlm.nih.gov/pubmed/37630749
http://dx.doi.org/10.3390/nu15163559
work_keys_str_mv AT mysoresaiprasadsindusha anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides
AT morenooliviagrace anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides
AT savaianodennisa anarrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides
AT mysoresaiprasadsindusha narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides
AT morenooliviagrace narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides
AT savaianodennisa narrativereviewofhumanclinicaltrialstoimprovelactosedigestionandtolerancebyfeedingbifidobacteriaorgalactooligosacharides