Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients

(1) Background: SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is a promising therapeutic target to fight COVID-19, and many RdRp inhibitors nucleotide/nucleoside analogs, such as remdesivir, have been identified or are in clinical studies. However, the appearance of resistant mutations could reduce...

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Detalles Bibliográficos
Autores principales: Gratteri, Carmen, Ambrosio, Francesca Alessandra, Lupia, Antonio, Moraca, Federica, Catalanotti, Bruno, Costa, Giosuè, Bellocchi, Maria, Carioti, Luca, Salpini, Romina, Ceccherini-Silberstein, Francesca, Frazia, Simone La, Malagnino, Vincenzo, Sarmati, Loredana, Svicher, Valentina, Bryant, Sharon, Artese, Anna, Alcaro, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459223/
https://www.ncbi.nlm.nih.gov/pubmed/37631058
http://dx.doi.org/10.3390/ph16081143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459223/
https://www.ncbi.nlm.nih.gov/pubmed/37631058
http://dx.doi.org/10.3390/ph16081143

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