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Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and o...

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Autores principales: Saraiva, Sofia M., Jacinto, Telma A., Gonçalves, Ana C., Gaspar, Dário, Silva, Luís R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459237/
https://www.ncbi.nlm.nih.gov/pubmed/37630983
http://dx.doi.org/10.3390/ph16081067
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author Saraiva, Sofia M.
Jacinto, Telma A.
Gonçalves, Ana C.
Gaspar, Dário
Silva, Luís R.
author_facet Saraiva, Sofia M.
Jacinto, Telma A.
Gonçalves, Ana C.
Gaspar, Dário
Silva, Luís R.
author_sort Saraiva, Sofia M.
collection PubMed
description Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of caffeine’s effects on cancer and cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel nanocarrier-based formulations, to enhance the bioavailability of caffeine and its beneficial effects will be discussed.
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spelling pubmed-104592372023-08-27 Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies Saraiva, Sofia M. Jacinto, Telma A. Gonçalves, Ana C. Gaspar, Dário Silva, Luís R. Pharmaceuticals (Basel) Review Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of caffeine’s effects on cancer and cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel nanocarrier-based formulations, to enhance the bioavailability of caffeine and its beneficial effects will be discussed. MDPI 2023-07-27 /pmc/articles/PMC10459237/ /pubmed/37630983 http://dx.doi.org/10.3390/ph16081067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saraiva, Sofia M.
Jacinto, Telma A.
Gonçalves, Ana C.
Gaspar, Dário
Silva, Luís R.
Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title_full Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title_fullStr Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title_full_unstemmed Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title_short Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
title_sort overview of caffeine effects on human health and emerging delivery strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459237/
https://www.ncbi.nlm.nih.gov/pubmed/37630983
http://dx.doi.org/10.3390/ph16081067
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