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Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459237/ https://www.ncbi.nlm.nih.gov/pubmed/37630983 http://dx.doi.org/10.3390/ph16081067 |
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author | Saraiva, Sofia M. Jacinto, Telma A. Gonçalves, Ana C. Gaspar, Dário Silva, Luís R. |
author_facet | Saraiva, Sofia M. Jacinto, Telma A. Gonçalves, Ana C. Gaspar, Dário Silva, Luís R. |
author_sort | Saraiva, Sofia M. |
collection | PubMed |
description | Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of caffeine’s effects on cancer and cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel nanocarrier-based formulations, to enhance the bioavailability of caffeine and its beneficial effects will be discussed. |
format | Online Article Text |
id | pubmed-10459237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104592372023-08-27 Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies Saraiva, Sofia M. Jacinto, Telma A. Gonçalves, Ana C. Gaspar, Dário Silva, Luís R. Pharmaceuticals (Basel) Review Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of caffeine’s effects on cancer and cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel nanocarrier-based formulations, to enhance the bioavailability of caffeine and its beneficial effects will be discussed. MDPI 2023-07-27 /pmc/articles/PMC10459237/ /pubmed/37630983 http://dx.doi.org/10.3390/ph16081067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Saraiva, Sofia M. Jacinto, Telma A. Gonçalves, Ana C. Gaspar, Dário Silva, Luís R. Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title | Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title_full | Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title_fullStr | Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title_full_unstemmed | Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title_short | Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies |
title_sort | overview of caffeine effects on human health and emerging delivery strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459237/ https://www.ncbi.nlm.nih.gov/pubmed/37630983 http://dx.doi.org/10.3390/ph16081067 |
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