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Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions

Viral replication fully relies on the host cell machinery, and physical interactions between viral and host proteins mediate key steps of the viral life cycle. Therefore, identifying virus–host protein–protein interactions (PPIs) provides insights into the molecular mechanisms governing virus infect...

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Detalles Bibliográficos
Autores principales: Dolata, Katarzyna Magdalena, Pei, Gang, Netherton, Christopher L., Karger, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459248/
https://www.ncbi.nlm.nih.gov/pubmed/37631977
http://dx.doi.org/10.3390/v15081634
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author Dolata, Katarzyna Magdalena
Pei, Gang
Netherton, Christopher L.
Karger, Axel
author_facet Dolata, Katarzyna Magdalena
Pei, Gang
Netherton, Christopher L.
Karger, Axel
author_sort Dolata, Katarzyna Magdalena
collection PubMed
description Viral replication fully relies on the host cell machinery, and physical interactions between viral and host proteins mediate key steps of the viral life cycle. Therefore, identifying virus–host protein–protein interactions (PPIs) provides insights into the molecular mechanisms governing virus infection and is crucial for designing novel antiviral strategies. In the case of the African swine fever virus (ASFV), a large DNA virus that causes a deadly panzootic disease in pigs, the limited understanding of host and viral targets hinders the development of effective vaccines and treatments. This review summarizes the current knowledge of virus–host and virus–virus PPIs by collecting and analyzing studies of individual viral proteins. We have compiled a dataset of experimentally determined host and virus protein targets, the molecular mechanisms involved, and the biological functions of the identified virus–host and virus–virus protein interactions during infection. Ultimately, this work provides a comprehensive and systematic overview of ASFV interactome, identifies knowledge gaps, and proposes future research directions.
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spelling pubmed-104592482023-08-27 Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions Dolata, Katarzyna Magdalena Pei, Gang Netherton, Christopher L. Karger, Axel Viruses Review Viral replication fully relies on the host cell machinery, and physical interactions between viral and host proteins mediate key steps of the viral life cycle. Therefore, identifying virus–host protein–protein interactions (PPIs) provides insights into the molecular mechanisms governing virus infection and is crucial for designing novel antiviral strategies. In the case of the African swine fever virus (ASFV), a large DNA virus that causes a deadly panzootic disease in pigs, the limited understanding of host and viral targets hinders the development of effective vaccines and treatments. This review summarizes the current knowledge of virus–host and virus–virus PPIs by collecting and analyzing studies of individual viral proteins. We have compiled a dataset of experimentally determined host and virus protein targets, the molecular mechanisms involved, and the biological functions of the identified virus–host and virus–virus protein interactions during infection. Ultimately, this work provides a comprehensive and systematic overview of ASFV interactome, identifies knowledge gaps, and proposes future research directions. MDPI 2023-07-27 /pmc/articles/PMC10459248/ /pubmed/37631977 http://dx.doi.org/10.3390/v15081634 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dolata, Katarzyna Magdalena
Pei, Gang
Netherton, Christopher L.
Karger, Axel
Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title_full Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title_fullStr Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title_full_unstemmed Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title_short Functional Landscape of African Swine Fever Virus–Host and Virus–Virus Protein Interactions
title_sort functional landscape of african swine fever virus–host and virus–virus protein interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459248/
https://www.ncbi.nlm.nih.gov/pubmed/37631977
http://dx.doi.org/10.3390/v15081634
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