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Development and Validation of a Novel UHPLC-MS/MS Method for the Quantification of Plinabulin in Plasma and Its Application in a Pharmacokinetic Study with Leukopenic Rats

Plinabulin, a new antitumor drug developed from marine natural products that targets microtubules in cancer cells, is currently being tested in a phase III clinical study. Plinabulin has been clinically proven to be effective on leukopenia. However, to our knowledge, there are no reports investigati...

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Detalles Bibliográficos
Autores principales:	Niu, Xiaochen, Chen, Dan, He, Wei, Tang, Yu, Zhao, Jianchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459361/ https://www.ncbi.nlm.nih.gov/pubmed/37631067 http://dx.doi.org/10.3390/ph16081153

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