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The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease

Research on the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its use as a therapeutic agent has grown over the past 30 years. Both in vitro and in vivo experiments have shown that PACAP exerts a strong neuroprotective effect in many central and peripheral...

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Autores principales: Cherait, Asma, Banks, William A., Vaudry, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459484/
https://www.ncbi.nlm.nih.gov/pubmed/37631246
http://dx.doi.org/10.3390/pharmaceutics15082032
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author Cherait, Asma
Banks, William A.
Vaudry, David
author_facet Cherait, Asma
Banks, William A.
Vaudry, David
author_sort Cherait, Asma
collection PubMed
description Research on the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its use as a therapeutic agent has grown over the past 30 years. Both in vitro and in vivo experiments have shown that PACAP exerts a strong neuroprotective effect in many central and peripheral neuronal diseases. Various delivery routes have been employed from intravenous (IV) injections to intracerebroventricular (ICV) administration, leading either to systemic or topical delivery of the peptide. Over the last decade, a growing interest in the use of intranasal (IN) administration of PACAP and other therapeutic agents has emerged as an alternative delivery route to target the brain. The aim of this review is to summarize the findings on the neuroprotective effect of PACAP and to discuss how the IN administration of PACAP could contribute to target the effects of this pleiotropic peptide.
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spelling pubmed-104594842023-08-27 The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease Cherait, Asma Banks, William A. Vaudry, David Pharmaceutics Review Research on the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its use as a therapeutic agent has grown over the past 30 years. Both in vitro and in vivo experiments have shown that PACAP exerts a strong neuroprotective effect in many central and peripheral neuronal diseases. Various delivery routes have been employed from intravenous (IV) injections to intracerebroventricular (ICV) administration, leading either to systemic or topical delivery of the peptide. Over the last decade, a growing interest in the use of intranasal (IN) administration of PACAP and other therapeutic agents has emerged as an alternative delivery route to target the brain. The aim of this review is to summarize the findings on the neuroprotective effect of PACAP and to discuss how the IN administration of PACAP could contribute to target the effects of this pleiotropic peptide. MDPI 2023-07-28 /pmc/articles/PMC10459484/ /pubmed/37631246 http://dx.doi.org/10.3390/pharmaceutics15082032 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cherait, Asma
Banks, William A.
Vaudry, David
The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title_full The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title_fullStr The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title_full_unstemmed The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title_short The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
title_sort potential of the nose-to-brain delivery of pacap for the treatment of neuronal disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459484/
https://www.ncbi.nlm.nih.gov/pubmed/37631246
http://dx.doi.org/10.3390/pharmaceutics15082032
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