Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry

Here, we report a tunable electrochemical benzylic C−H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant. The benzylic C−H functionalization can be well controlled by varying the electrochemical conditions, affording t...

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Detalles Bibliográficos
Autores principales: Wang, Changji, Yang, Na, Li, Chao, He, Jian, Li, Hongji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459638/
https://www.ncbi.nlm.nih.gov/pubmed/37630392
http://dx.doi.org/10.3390/molecules28166139
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author Wang, Changji
Yang, Na
Li, Chao
He, Jian
Li, Hongji
author_facet Wang, Changji
Yang, Na
Li, Chao
He, Jian
Li, Hongji
author_sort Wang, Changji
collection PubMed
description Here, we report a tunable electrochemical benzylic C−H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant. The benzylic C−H functionalization can be well controlled by varying the electrochemical conditions, affording the specific coupling products via C−C and C−N bond formation.
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spelling pubmed-104596382023-08-27 Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry Wang, Changji Yang, Na Li, Chao He, Jian Li, Hongji Molecules Article Here, we report a tunable electrochemical benzylic C−H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant. The benzylic C−H functionalization can be well controlled by varying the electrochemical conditions, affording the specific coupling products via C−C and C−N bond formation. MDPI 2023-08-19 /pmc/articles/PMC10459638/ /pubmed/37630392 http://dx.doi.org/10.3390/molecules28166139 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Changji
Yang, Na
Li, Chao
He, Jian
Li, Hongji
Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title_full Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title_fullStr Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title_full_unstemmed Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title_short Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
title_sort tuning benzylic c−h functionalization of (thio)xanthenes with electrochemistry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459638/
https://www.ncbi.nlm.nih.gov/pubmed/37630392
http://dx.doi.org/10.3390/molecules28166139
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