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Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †

The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high num...

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Autores principales: Caminade, Anne-Marie, Milewski, Max, Hey-Hawkins, Evamarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459656/
https://www.ncbi.nlm.nih.gov/pubmed/37631334
http://dx.doi.org/10.3390/pharmaceutics15082117
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author Caminade, Anne-Marie
Milewski, Max
Hey-Hawkins, Evamarie
author_facet Caminade, Anne-Marie
Milewski, Max
Hey-Hawkins, Evamarie
author_sort Caminade, Anne-Marie
collection PubMed
description The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high number of boron atoms in a single entity has emerged many years ago. In this perspective, using hyper-branched macromolecules such as dendrimers appears as an interesting solution. In this review, we will first present the synthesis of diverse dendritic entities (dendrimers, dendrons, and Janus dendrimers) that incorporate boron clusters, in particular carboranes, anywhere in their structure. Four parts of this review present the synthesis of dendrimers having boron clusters on the surface, or inside their structure, of dendrons and of Janus dendrimers, bearing boron clusters. Practically all these boronated dendritic structures were synthesized with the objective to study their biological properties, but in fact only a few of them have been tested against cancerous cells, and even a smaller number was tested in BNCT experiments. The biological experiments are discussed in the fifth part of this review. A good efficiency is generally observed with the boronated dendrimers, even in animal models, with an increase in their mean survival time (MST).
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spelling pubmed-104596562023-08-27 Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties † Caminade, Anne-Marie Milewski, Max Hey-Hawkins, Evamarie Pharmaceutics Review The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high number of boron atoms in a single entity has emerged many years ago. In this perspective, using hyper-branched macromolecules such as dendrimers appears as an interesting solution. In this review, we will first present the synthesis of diverse dendritic entities (dendrimers, dendrons, and Janus dendrimers) that incorporate boron clusters, in particular carboranes, anywhere in their structure. Four parts of this review present the synthesis of dendrimers having boron clusters on the surface, or inside their structure, of dendrons and of Janus dendrimers, bearing boron clusters. Practically all these boronated dendritic structures were synthesized with the objective to study their biological properties, but in fact only a few of them have been tested against cancerous cells, and even a smaller number was tested in BNCT experiments. The biological experiments are discussed in the fifth part of this review. A good efficiency is generally observed with the boronated dendrimers, even in animal models, with an increase in their mean survival time (MST). MDPI 2023-08-10 /pmc/articles/PMC10459656/ /pubmed/37631334 http://dx.doi.org/10.3390/pharmaceutics15082117 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caminade, Anne-Marie
Milewski, Max
Hey-Hawkins, Evamarie
Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title_full Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title_fullStr Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title_full_unstemmed Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title_short Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties †
title_sort dendritic structures functionalized with boron clusters, in particular carboranes, and their biological properties †
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459656/
https://www.ncbi.nlm.nih.gov/pubmed/37631334
http://dx.doi.org/10.3390/pharmaceutics15082117
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