Cargando…

Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study

Low vitamin D (VitD) level is a risk factor for preterm birth (PTB), but the results of previous studies remained inconsistent, which may be influenced by the confounding factors and different types of PTB. We performed Mendelian randomization (MR) to uncover the association of 25-hydroxyvitamin D (...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Haoyue, Chi, Peihan, Zhuang, Yan, Alifu, Xialidan, Zhou, Haibo, Qiu, Yiwen, Huang, Ye, Zhang, Libi, Ainiwan, Diliyaer, Peng, Zhicheng, Si, Shuting, Liu, Hui, Yu, Yunxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459690/
https://www.ncbi.nlm.nih.gov/pubmed/37630783
http://dx.doi.org/10.3390/nu15163593
_version_ 1785097472393084928
author Cheng, Haoyue
Chi, Peihan
Zhuang, Yan
Alifu, Xialidan
Zhou, Haibo
Qiu, Yiwen
Huang, Ye
Zhang, Libi
Ainiwan, Diliyaer
Peng, Zhicheng
Si, Shuting
Liu, Hui
Yu, Yunxian
author_facet Cheng, Haoyue
Chi, Peihan
Zhuang, Yan
Alifu, Xialidan
Zhou, Haibo
Qiu, Yiwen
Huang, Ye
Zhang, Libi
Ainiwan, Diliyaer
Peng, Zhicheng
Si, Shuting
Liu, Hui
Yu, Yunxian
author_sort Cheng, Haoyue
collection PubMed
description Low vitamin D (VitD) level is a risk factor for preterm birth (PTB), but the results of previous studies remained inconsistent, which may be influenced by the confounding factors and different types of PTB. We performed Mendelian randomization (MR) to uncover the association of 25-hydroxyvitamin D (25(OH)D) with PTB, premature rupture of membranes (PROM), and preterm premature rupture of membranes (PPROM). This study was conducted in Zhoushan Maternal and Child Health Hospital, Zhejiang, from August 2011 to March 2022. Plasma 25(OH)D levels in three trimesters of pregnancy were measured. We conducted an MR analysis utilizing a genetic risk score (GRS) approach, which was based on VitD-associated single-nucleotide polymorphisms. The prospective cohort study included 3923 pregnant women. The prevalence of PTB, PROM, and PPROM were 6.09%, 13.18%, and 1.33%, respectively. Compared to those without vitamin D deficiency (VDD), only vaginally delivering pregnant women with VDD had a 2.69 (1.08–6.68) times risk of PTB. However, MR analysis did not support the association. One-unit higher GRS was not associated with an increased risk of PTB, regardless of the trimesters (OR [95% CI]: 1.01 [0.93–1.10], 1.06 [0.96–1.18], and 0.95 [0.82–1.10], respectively). When further taking PROM and PPROM as the outcomes, the MR analysis also showed no consistent evidence of a causal effect of VitD levels on the risk of them. Our MR analyses did not support a causal effect of 25(OH)D concentrations in the three trimesters on PTB, PROM, and PPROM.
format Online
Article
Text
id pubmed-10459690
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104596902023-08-27 Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study Cheng, Haoyue Chi, Peihan Zhuang, Yan Alifu, Xialidan Zhou, Haibo Qiu, Yiwen Huang, Ye Zhang, Libi Ainiwan, Diliyaer Peng, Zhicheng Si, Shuting Liu, Hui Yu, Yunxian Nutrients Article Low vitamin D (VitD) level is a risk factor for preterm birth (PTB), but the results of previous studies remained inconsistent, which may be influenced by the confounding factors and different types of PTB. We performed Mendelian randomization (MR) to uncover the association of 25-hydroxyvitamin D (25(OH)D) with PTB, premature rupture of membranes (PROM), and preterm premature rupture of membranes (PPROM). This study was conducted in Zhoushan Maternal and Child Health Hospital, Zhejiang, from August 2011 to March 2022. Plasma 25(OH)D levels in three trimesters of pregnancy were measured. We conducted an MR analysis utilizing a genetic risk score (GRS) approach, which was based on VitD-associated single-nucleotide polymorphisms. The prospective cohort study included 3923 pregnant women. The prevalence of PTB, PROM, and PPROM were 6.09%, 13.18%, and 1.33%, respectively. Compared to those without vitamin D deficiency (VDD), only vaginally delivering pregnant women with VDD had a 2.69 (1.08–6.68) times risk of PTB. However, MR analysis did not support the association. One-unit higher GRS was not associated with an increased risk of PTB, regardless of the trimesters (OR [95% CI]: 1.01 [0.93–1.10], 1.06 [0.96–1.18], and 0.95 [0.82–1.10], respectively). When further taking PROM and PPROM as the outcomes, the MR analysis also showed no consistent evidence of a causal effect of VitD levels on the risk of them. Our MR analyses did not support a causal effect of 25(OH)D concentrations in the three trimesters on PTB, PROM, and PPROM. MDPI 2023-08-16 /pmc/articles/PMC10459690/ /pubmed/37630783 http://dx.doi.org/10.3390/nu15163593 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Haoyue
Chi, Peihan
Zhuang, Yan
Alifu, Xialidan
Zhou, Haibo
Qiu, Yiwen
Huang, Ye
Zhang, Libi
Ainiwan, Diliyaer
Peng, Zhicheng
Si, Shuting
Liu, Hui
Yu, Yunxian
Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title_full Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title_fullStr Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title_full_unstemmed Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title_short Association of 25-Hydroxyvitamin D with Preterm Birth and Premature Rupture of Membranes: A Mendelian Randomization Study
title_sort association of 25-hydroxyvitamin d with preterm birth and premature rupture of membranes: a mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459690/
https://www.ncbi.nlm.nih.gov/pubmed/37630783
http://dx.doi.org/10.3390/nu15163593
work_keys_str_mv AT chenghaoyue associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT chipeihan associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT zhuangyan associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT alifuxialidan associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT zhouhaibo associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT qiuyiwen associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT huangye associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT zhanglibi associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT ainiwandiliyaer associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT pengzhicheng associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT sishuting associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT liuhui associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy
AT yuyunxian associationof25hydroxyvitamindwithpretermbirthandprematureruptureofmembranesamendelianrandomizationstudy