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Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects

Indoleamine-2,3-dioxygenase 1 (IDO1) and signal transducer and activator of transcription 3 (STAT3) have emerged as significant targets in the tumor microenvironment for cancer therapy. In this study, we synthesized three novel 2-amino-1,4-naphthoquinone amide-oxime derivatives and identified them a...

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Detalles Bibliográficos
Autores principales:	Huang, Ri-Zhen, Liang, Qiao-Ling, Jing, Xiao-Teng, Wang, Ke, Zhang, Hui-Yong, Wang, Heng-Shan, Ma, Xian-Li, Wei, Jian-Hua, Zhang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459814/ https://www.ncbi.nlm.nih.gov/pubmed/37630387 http://dx.doi.org/10.3390/molecules28166135

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