Cargando…

Updates in Culture-Negative Endocarditis

Blood culture-negative infective endocarditis (BCNE) is a challenging condition associated with significant morbidity and mortality. This review discusses the epidemiology, microbiology, diagnosis, and treatment of BCNE considering advancements in molecular diagnostics and increased access to cardia...

Descripción completa

Detalles Bibliográficos
Autores principales: McHugh, Jack, Saleh, Omar Abu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459830/
https://www.ncbi.nlm.nih.gov/pubmed/37623987
http://dx.doi.org/10.3390/pathogens12081027
_version_ 1785097506039791616
author McHugh, Jack
Saleh, Omar Abu
author_facet McHugh, Jack
Saleh, Omar Abu
author_sort McHugh, Jack
collection PubMed
description Blood culture-negative infective endocarditis (BCNE) is a challenging condition associated with significant morbidity and mortality. This review discusses the epidemiology, microbiology, diagnosis, and treatment of BCNE considering advancements in molecular diagnostics and increased access to cardiac surgery. BCNE can be categorized into bacterial endocarditis with sterilized blood cultures due to previous antibiotic treatment, endocarditis caused by fastidious microorganisms, and true BCNE caused by intracellular organisms that cannot be cultured using traditional techniques. Non-infectious causes such as nonbacterial thrombotic endocarditis should also be considered. Diagnostic approaches involve thorough patient history; blood and serum testing, including appropriate handling of blood cultures; serological testing; and molecular techniques such as targeted and shotgun metagenomic sequencing. Where available, evaluation of explanted cardiac tissue through histopathology and molecular techniques is crucial. The therapy for BCNE depends on the likely causative agent and the presence of prosthetic material, with surgical intervention often required.
format Online
Article
Text
id pubmed-10459830
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104598302023-08-27 Updates in Culture-Negative Endocarditis McHugh, Jack Saleh, Omar Abu Pathogens Review Blood culture-negative infective endocarditis (BCNE) is a challenging condition associated with significant morbidity and mortality. This review discusses the epidemiology, microbiology, diagnosis, and treatment of BCNE considering advancements in molecular diagnostics and increased access to cardiac surgery. BCNE can be categorized into bacterial endocarditis with sterilized blood cultures due to previous antibiotic treatment, endocarditis caused by fastidious microorganisms, and true BCNE caused by intracellular organisms that cannot be cultured using traditional techniques. Non-infectious causes such as nonbacterial thrombotic endocarditis should also be considered. Diagnostic approaches involve thorough patient history; blood and serum testing, including appropriate handling of blood cultures; serological testing; and molecular techniques such as targeted and shotgun metagenomic sequencing. Where available, evaluation of explanted cardiac tissue through histopathology and molecular techniques is crucial. The therapy for BCNE depends on the likely causative agent and the presence of prosthetic material, with surgical intervention often required. MDPI 2023-08-10 /pmc/articles/PMC10459830/ /pubmed/37623987 http://dx.doi.org/10.3390/pathogens12081027 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McHugh, Jack
Saleh, Omar Abu
Updates in Culture-Negative Endocarditis
title Updates in Culture-Negative Endocarditis
title_full Updates in Culture-Negative Endocarditis
title_fullStr Updates in Culture-Negative Endocarditis
title_full_unstemmed Updates in Culture-Negative Endocarditis
title_short Updates in Culture-Negative Endocarditis
title_sort updates in culture-negative endocarditis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459830/
https://www.ncbi.nlm.nih.gov/pubmed/37623987
http://dx.doi.org/10.3390/pathogens12081027
work_keys_str_mv AT mchughjack updatesinculturenegativeendocarditis
AT salehomarabu updatesinculturenegativeendocarditis