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The Intestinal Microbiome after Traumatic Injury

The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have been studied as an area of interest in the dysreg...

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Autores principales: Munley, Jennifer A., Kirkpatrick, Stacey L., Gillies, Gwendolyn S., Bible, Letitia E., Efron, Philip A., Nagpal, Ravinder, Mohr, Alicia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459834/
https://www.ncbi.nlm.nih.gov/pubmed/37630549
http://dx.doi.org/10.3390/microorganisms11081990
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author Munley, Jennifer A.
Kirkpatrick, Stacey L.
Gillies, Gwendolyn S.
Bible, Letitia E.
Efron, Philip A.
Nagpal, Ravinder
Mohr, Alicia M.
author_facet Munley, Jennifer A.
Kirkpatrick, Stacey L.
Gillies, Gwendolyn S.
Bible, Letitia E.
Efron, Philip A.
Nagpal, Ravinder
Mohr, Alicia M.
author_sort Munley, Jennifer A.
collection PubMed
description The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have been studied as an area of interest in the dysregulation of immune function and systemic inflammation which occur after trauma. These studies also demonstrate changes in gut microbiome diversity and even microbial composition, with a transition to a pathobiome state. In addition, sex has been identified as a biological variable influencing alterations in the microbiome after trauma. Therapeutics such as fecal transplantation have been utilized to ameliorate not only these microbiome changes but may also play a role in recovery postinjury. This review summarizes the alterations in the gut microbiome that occur postinjury, either in isolated injury or multiple injuries, along with proposed mechanisms for these changes and future directions for the field.
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spelling pubmed-104598342023-08-27 The Intestinal Microbiome after Traumatic Injury Munley, Jennifer A. Kirkpatrick, Stacey L. Gillies, Gwendolyn S. Bible, Letitia E. Efron, Philip A. Nagpal, Ravinder Mohr, Alicia M. Microorganisms Review The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have been studied as an area of interest in the dysregulation of immune function and systemic inflammation which occur after trauma. These studies also demonstrate changes in gut microbiome diversity and even microbial composition, with a transition to a pathobiome state. In addition, sex has been identified as a biological variable influencing alterations in the microbiome after trauma. Therapeutics such as fecal transplantation have been utilized to ameliorate not only these microbiome changes but may also play a role in recovery postinjury. This review summarizes the alterations in the gut microbiome that occur postinjury, either in isolated injury or multiple injuries, along with proposed mechanisms for these changes and future directions for the field. MDPI 2023-08-02 /pmc/articles/PMC10459834/ /pubmed/37630549 http://dx.doi.org/10.3390/microorganisms11081990 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Munley, Jennifer A.
Kirkpatrick, Stacey L.
Gillies, Gwendolyn S.
Bible, Letitia E.
Efron, Philip A.
Nagpal, Ravinder
Mohr, Alicia M.
The Intestinal Microbiome after Traumatic Injury
title The Intestinal Microbiome after Traumatic Injury
title_full The Intestinal Microbiome after Traumatic Injury
title_fullStr The Intestinal Microbiome after Traumatic Injury
title_full_unstemmed The Intestinal Microbiome after Traumatic Injury
title_short The Intestinal Microbiome after Traumatic Injury
title_sort intestinal microbiome after traumatic injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459834/
https://www.ncbi.nlm.nih.gov/pubmed/37630549
http://dx.doi.org/10.3390/microorganisms11081990
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