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Evaluation of Pharmacokinetic Feasibility of Febuxostat/L-pyroglutamic Acid Cocrystals in Rats and Mice

Febuxostat (FBX), a selective xanthine oxidase inhibitor, belongs to BCS class II, showing low solubility and high permeability with a moderate F value (<49%). Recently, FBX/L-pyroglutamic acid cocrystal (FBX-PG) was developed with an improving 4-fold increase of FBX solubility. Nevertheless, the...

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Detalles Bibliográficos
Autores principales:	Yu, Jeong-Eun, You, Byoung Hoon, Bae, Mingoo, Han, Seung Yon, Jung, Kiwon, Choi, Young Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459842/ https://www.ncbi.nlm.nih.gov/pubmed/37631381 http://dx.doi.org/10.3390/pharmaceutics15082167

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