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Is Slovakia Almost a Hepatitis D Free Country?

Background: It is assumed that the prevalence of hepatitis D in HBsAg-positive individuals reaches 4.5–13% in the world and on average about 3% in Europe. Data from several European countries, including Slovakia, are missing or are from an older period. Methods: We analyzed all available data on hep...

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Autores principales: Kristian, Pavol, Hockicková, Ivana, Hatalová, Elena, Žilinčanová, Daniela, Rác, Marek, Bednárová, Veronika, Lenártová, Patrícia Denisa, Dražilová, Sylvia, Skladaný, Ľubomír, Schréter, Ivan, Jarčuška, Peter, Halánová, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459979/
https://www.ncbi.nlm.nih.gov/pubmed/37632037
http://dx.doi.org/10.3390/v15081695
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author Kristian, Pavol
Hockicková, Ivana
Hatalová, Elena
Žilinčanová, Daniela
Rác, Marek
Bednárová, Veronika
Lenártová, Patrícia Denisa
Dražilová, Sylvia
Skladaný, Ľubomír
Schréter, Ivan
Jarčuška, Peter
Halánová, Monika
author_facet Kristian, Pavol
Hockicková, Ivana
Hatalová, Elena
Žilinčanová, Daniela
Rác, Marek
Bednárová, Veronika
Lenártová, Patrícia Denisa
Dražilová, Sylvia
Skladaný, Ľubomír
Schréter, Ivan
Jarčuška, Peter
Halánová, Monika
author_sort Kristian, Pavol
collection PubMed
description Background: It is assumed that the prevalence of hepatitis D in HBsAg-positive individuals reaches 4.5–13% in the world and on average about 3% in Europe. Data from several European countries, including Slovakia, are missing or are from an older period. Methods: We analyzed all available data on hepatitis D from Slovakia, including reports from the Slovak Public Health Authority and the results of one prospective study, and three smaller surveys. The determination of anti-HDV IgG and IgM antibodies and/or HDV RNA was used to detect hepatitis D. Results: In the years 2005–2022, no confirmed case of acute or chronic HDV infection was reported in Slovakia. The presented survey includes a total of 343 patients, of which 126 were asymptomatic HBsAg carriers, 33 acute hepatitis B, and 184 chronic hepatitis B cases. In a recent prospective study of 206 HBsAg-positive patients who were completely serologically and virologically examined for hepatitis B and D, only 1 anti-HDV IgG-positive and no anti-HDV IgM or HDV RNA-positive cases were detected. In other smaller surveys, two anti-HDV IgG-positive patients were found without the possibility of HDV RNA confirmation. In total, only 3 of 329 HBsAg-positive patients (0.91%) tested positive for anti-HDV IgG antibodies, and none of 220 tested positive for HDV RNA. Conclusion: The available data show that Slovakia is one of the countries with a very low prevalence of HDV infection, reaching less than 1% in HBsAg-positive patients. Routine testing for hepatitis D is lacking in Slovakia, and therefore it is necessary to implement testing of all HBsAg-positive individuals according to international recommendations.
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spelling pubmed-104599792023-08-27 Is Slovakia Almost a Hepatitis D Free Country? Kristian, Pavol Hockicková, Ivana Hatalová, Elena Žilinčanová, Daniela Rác, Marek Bednárová, Veronika Lenártová, Patrícia Denisa Dražilová, Sylvia Skladaný, Ľubomír Schréter, Ivan Jarčuška, Peter Halánová, Monika Viruses Article Background: It is assumed that the prevalence of hepatitis D in HBsAg-positive individuals reaches 4.5–13% in the world and on average about 3% in Europe. Data from several European countries, including Slovakia, are missing or are from an older period. Methods: We analyzed all available data on hepatitis D from Slovakia, including reports from the Slovak Public Health Authority and the results of one prospective study, and three smaller surveys. The determination of anti-HDV IgG and IgM antibodies and/or HDV RNA was used to detect hepatitis D. Results: In the years 2005–2022, no confirmed case of acute or chronic HDV infection was reported in Slovakia. The presented survey includes a total of 343 patients, of which 126 were asymptomatic HBsAg carriers, 33 acute hepatitis B, and 184 chronic hepatitis B cases. In a recent prospective study of 206 HBsAg-positive patients who were completely serologically and virologically examined for hepatitis B and D, only 1 anti-HDV IgG-positive and no anti-HDV IgM or HDV RNA-positive cases were detected. In other smaller surveys, two anti-HDV IgG-positive patients were found without the possibility of HDV RNA confirmation. In total, only 3 of 329 HBsAg-positive patients (0.91%) tested positive for anti-HDV IgG antibodies, and none of 220 tested positive for HDV RNA. Conclusion: The available data show that Slovakia is one of the countries with a very low prevalence of HDV infection, reaching less than 1% in HBsAg-positive patients. Routine testing for hepatitis D is lacking in Slovakia, and therefore it is necessary to implement testing of all HBsAg-positive individuals according to international recommendations. MDPI 2023-08-05 /pmc/articles/PMC10459979/ /pubmed/37632037 http://dx.doi.org/10.3390/v15081695 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kristian, Pavol
Hockicková, Ivana
Hatalová, Elena
Žilinčanová, Daniela
Rác, Marek
Bednárová, Veronika
Lenártová, Patrícia Denisa
Dražilová, Sylvia
Skladaný, Ľubomír
Schréter, Ivan
Jarčuška, Peter
Halánová, Monika
Is Slovakia Almost a Hepatitis D Free Country?
title Is Slovakia Almost a Hepatitis D Free Country?
title_full Is Slovakia Almost a Hepatitis D Free Country?
title_fullStr Is Slovakia Almost a Hepatitis D Free Country?
title_full_unstemmed Is Slovakia Almost a Hepatitis D Free Country?
title_short Is Slovakia Almost a Hepatitis D Free Country?
title_sort is slovakia almost a hepatitis d free country?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459979/
https://www.ncbi.nlm.nih.gov/pubmed/37632037
http://dx.doi.org/10.3390/v15081695
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