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Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advan...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460071/ https://www.ncbi.nlm.nih.gov/pubmed/37631542 http://dx.doi.org/10.3390/polym15163485 |
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author | Herdiana, Yedi |
author_facet | Herdiana, Yedi |
author_sort | Herdiana, Yedi |
collection | PubMed |
description | Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advantages, including biocompatibility, biodegradability, and targeted drug delivery capabilities. CSNPs have been extensively studied due to their ability to encapsulate and release medications in a controlled manner. Different nanoparticle (NP) delivery systems, including gels, microspheres, and coatings, have been developed to enhance drug retention, drug targeting, and controlled release in the esophagus. These nanoparticles can target specific molecular pathways associated with acid regulation, esophageal tissue protection, and inflammation modulation. However, the optimization of nanoparticle formulations faces challenges, including ensuring stability, scalability, and regulatory compliance. The future may see CSNPs combined with other treatments like proton pump inhibitors (PPIs) or mucosal protectants for a synergistic therapeutic approach. Thus, CSNPs provide exciting opportunities for novel GERD treatment strategies. |
format | Online Article Text |
id | pubmed-10460071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104600712023-08-27 Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment Herdiana, Yedi Polymers (Basel) Review Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advantages, including biocompatibility, biodegradability, and targeted drug delivery capabilities. CSNPs have been extensively studied due to their ability to encapsulate and release medications in a controlled manner. Different nanoparticle (NP) delivery systems, including gels, microspheres, and coatings, have been developed to enhance drug retention, drug targeting, and controlled release in the esophagus. These nanoparticles can target specific molecular pathways associated with acid regulation, esophageal tissue protection, and inflammation modulation. However, the optimization of nanoparticle formulations faces challenges, including ensuring stability, scalability, and regulatory compliance. The future may see CSNPs combined with other treatments like proton pump inhibitors (PPIs) or mucosal protectants for a synergistic therapeutic approach. Thus, CSNPs provide exciting opportunities for novel GERD treatment strategies. MDPI 2023-08-20 /pmc/articles/PMC10460071/ /pubmed/37631542 http://dx.doi.org/10.3390/polym15163485 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Herdiana, Yedi Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title | Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title_full | Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title_fullStr | Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title_full_unstemmed | Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title_short | Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment |
title_sort | chitosan nanoparticles for gastroesophageal reflux disease treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460071/ https://www.ncbi.nlm.nih.gov/pubmed/37631542 http://dx.doi.org/10.3390/polym15163485 |
work_keys_str_mv | AT herdianayedi chitosannanoparticlesforgastroesophagealrefluxdiseasetreatment |