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Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment

Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advan...

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Autor principal: Herdiana, Yedi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460071/
https://www.ncbi.nlm.nih.gov/pubmed/37631542
http://dx.doi.org/10.3390/polym15163485
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author Herdiana, Yedi
author_facet Herdiana, Yedi
author_sort Herdiana, Yedi
collection PubMed
description Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advantages, including biocompatibility, biodegradability, and targeted drug delivery capabilities. CSNPs have been extensively studied due to their ability to encapsulate and release medications in a controlled manner. Different nanoparticle (NP) delivery systems, including gels, microspheres, and coatings, have been developed to enhance drug retention, drug targeting, and controlled release in the esophagus. These nanoparticles can target specific molecular pathways associated with acid regulation, esophageal tissue protection, and inflammation modulation. However, the optimization of nanoparticle formulations faces challenges, including ensuring stability, scalability, and regulatory compliance. The future may see CSNPs combined with other treatments like proton pump inhibitors (PPIs) or mucosal protectants for a synergistic therapeutic approach. Thus, CSNPs provide exciting opportunities for novel GERD treatment strategies.
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spelling pubmed-104600712023-08-27 Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment Herdiana, Yedi Polymers (Basel) Review Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advantages, including biocompatibility, biodegradability, and targeted drug delivery capabilities. CSNPs have been extensively studied due to their ability to encapsulate and release medications in a controlled manner. Different nanoparticle (NP) delivery systems, including gels, microspheres, and coatings, have been developed to enhance drug retention, drug targeting, and controlled release in the esophagus. These nanoparticles can target specific molecular pathways associated with acid regulation, esophageal tissue protection, and inflammation modulation. However, the optimization of nanoparticle formulations faces challenges, including ensuring stability, scalability, and regulatory compliance. The future may see CSNPs combined with other treatments like proton pump inhibitors (PPIs) or mucosal protectants for a synergistic therapeutic approach. Thus, CSNPs provide exciting opportunities for novel GERD treatment strategies. MDPI 2023-08-20 /pmc/articles/PMC10460071/ /pubmed/37631542 http://dx.doi.org/10.3390/polym15163485 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herdiana, Yedi
Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title_full Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title_fullStr Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title_full_unstemmed Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title_short Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment
title_sort chitosan nanoparticles for gastroesophageal reflux disease treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460071/
https://www.ncbi.nlm.nih.gov/pubmed/37631542
http://dx.doi.org/10.3390/polym15163485
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