Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding

Afibrinogenemia is an extremely rare bleeding disorder characterized by the absence or severe deficiency of fibrinogen, a major protein involved in the regulation of blood clotting. This disorder can have both hemorrhagic and/or thrombotic manifestations. We present the case of a female neonate who...

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Autores principales: Salah, Qais M, AlRashayda, Rami R, Heresh, Mohammad J, Abulehya, Aya, Salah Al-deen, Leena W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460120/
https://www.ncbi.nlm.nih.gov/pubmed/37637664
http://dx.doi.org/10.7759/cureus.42542
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author Salah, Qais M
AlRashayda, Rami R
Heresh, Mohammad J
Abulehya, Aya
Salah Al-deen, Leena W
author_facet Salah, Qais M
AlRashayda, Rami R
Heresh, Mohammad J
Abulehya, Aya
Salah Al-deen, Leena W
author_sort Salah, Qais M
collection PubMed
description Afibrinogenemia is an extremely rare bleeding disorder characterized by the absence or severe deficiency of fibrinogen, a major protein involved in the regulation of blood clotting. This disorder can have both hemorrhagic and/or thrombotic manifestations. We present the case of a female neonate who was diagnosed with congenital afibrinogenemia within the first two weeks of life. The patient presented with persistent bleeding from the umbilical stump, prompting a thorough investigation and workup. Early diagnosis and management were essential to preventing life-threatening bleeding events.
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spelling pubmed-104601202023-08-27 Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding Salah, Qais M AlRashayda, Rami R Heresh, Mohammad J Abulehya, Aya Salah Al-deen, Leena W Cureus Pediatrics Afibrinogenemia is an extremely rare bleeding disorder characterized by the absence or severe deficiency of fibrinogen, a major protein involved in the regulation of blood clotting. This disorder can have both hemorrhagic and/or thrombotic manifestations. We present the case of a female neonate who was diagnosed with congenital afibrinogenemia within the first two weeks of life. The patient presented with persistent bleeding from the umbilical stump, prompting a thorough investigation and workup. Early diagnosis and management were essential to preventing life-threatening bleeding events. Cureus 2023-07-27 /pmc/articles/PMC10460120/ /pubmed/37637664 http://dx.doi.org/10.7759/cureus.42542 Text en Copyright © 2023, Salah et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Salah, Qais M
AlRashayda, Rami R
Heresh, Mohammad J
Abulehya, Aya
Salah Al-deen, Leena W
Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title_full Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title_fullStr Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title_full_unstemmed Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title_short Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding
title_sort early diagnosis and management of congenital afibrinogenemia: a case report of umbilical stump bleeding
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460120/
https://www.ncbi.nlm.nih.gov/pubmed/37637664
http://dx.doi.org/10.7759/cureus.42542
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