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Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report

Invasive pulmonary aspergillosis (IPA) in liver transplant patients remains rare but exceedingly fatal. The diagnostic challenges associated with this condition are compounded by its infrequent onset within the first two weeks following transplantation. Moreover, therapeutic management is complex du...

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Autores principales: Espinosa-Leon, Juan P, Feng, Theresa, de Lima, Andres, O'Gara, Brian P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460166/
https://www.ncbi.nlm.nih.gov/pubmed/37637622
http://dx.doi.org/10.7759/cureus.42554
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author Espinosa-Leon, Juan P
Feng, Theresa
de Lima, Andres
O'Gara, Brian P
author_facet Espinosa-Leon, Juan P
Feng, Theresa
de Lima, Andres
O'Gara, Brian P
author_sort Espinosa-Leon, Juan P
collection PubMed
description Invasive pulmonary aspergillosis (IPA) in liver transplant patients remains rare but exceedingly fatal. The diagnostic challenges associated with this condition are compounded by its infrequent onset within the first two weeks following transplantation. Moreover, therapeutic management is complex due to the intricate drug interactions between triazole antifungals and calcineurin inhibitor immunosuppressants. We present the case of a 63-year-old male who underwent uncomplicated liver transplantation (LT) and developed early-onset IPA. Despite maximal efforts, the patient expired. This report aims to underscore the vital importance of timely diagnosis and therapy in preventing the insidious progression of invasive disease and subsequent mortality.
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spelling pubmed-104601662023-08-27 Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report Espinosa-Leon, Juan P Feng, Theresa de Lima, Andres O'Gara, Brian P Cureus Anesthesiology Invasive pulmonary aspergillosis (IPA) in liver transplant patients remains rare but exceedingly fatal. The diagnostic challenges associated with this condition are compounded by its infrequent onset within the first two weeks following transplantation. Moreover, therapeutic management is complex due to the intricate drug interactions between triazole antifungals and calcineurin inhibitor immunosuppressants. We present the case of a 63-year-old male who underwent uncomplicated liver transplantation (LT) and developed early-onset IPA. Despite maximal efforts, the patient expired. This report aims to underscore the vital importance of timely diagnosis and therapy in preventing the insidious progression of invasive disease and subsequent mortality. Cureus 2023-07-27 /pmc/articles/PMC10460166/ /pubmed/37637622 http://dx.doi.org/10.7759/cureus.42554 Text en Copyright © 2023, Espinosa-Leon et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Anesthesiology
Espinosa-Leon, Juan P
Feng, Theresa
de Lima, Andres
O'Gara, Brian P
Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title_full Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title_fullStr Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title_full_unstemmed Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title_short Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report
title_sort early-onset invasive pulmonary aspergillosis in a liver transplant patient: a case report
topic Anesthesiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460166/
https://www.ncbi.nlm.nih.gov/pubmed/37637622
http://dx.doi.org/10.7759/cureus.42554
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