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Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease

OBJECTIVE: This study aims to compare the superficial vascular density from the macular region and the retinal nerve fiber layer (RNFL) thickness from the optic disc region between Parkinson’s disease (PD) patients and controls. METHODS: We enrolled 56 idiopathic PD patients, totaling 86 eyes (PD gr...

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Autores principales: Tu, Min, Yang, Shuangfeng, Zeng, Lan, Tan, Yuling, Wang, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460207/
https://www.ncbi.nlm.nih.gov/pubmed/37637710
http://dx.doi.org/10.2147/IJGM.S426501
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author Tu, Min
Yang, Shuangfeng
Zeng, Lan
Tan, Yuling
Wang, Xiaoming
author_facet Tu, Min
Yang, Shuangfeng
Zeng, Lan
Tan, Yuling
Wang, Xiaoming
author_sort Tu, Min
collection PubMed
description OBJECTIVE: This study aims to compare the superficial vascular density from the macular region and the retinal nerve fiber layer (RNFL) thickness from the optic disc region between Parkinson’s disease (PD) patients and controls. METHODS: We enrolled 56 idiopathic PD patients, totaling 86 eyes (PD group), and 45 sex- and age-matched healthy individuals, amounting to 90 eyes (control group). All subjects underwent examination using Zeiss wide-field vascular optical coherence tomography (OCT) (Cirrus HD-OCT 5000 Carl Zeiss, Germany), with a scanning range of 3 mm × 3 mm. We divided the images into two concentric circles with diameters of 1 mm and 3 mm at the macular fovea’s center. Patients with PD were evaluated during their “off” phase using the Unified Parkinson’s Disease Rating Scale III (UPDRS-III) and the Hoehn-Yahr scale (H-Y scale) to assess disease severity. RESULTS: The PD group exhibited significantly lower RNFL thickness (106.13±12.36 μm) compared to the control group (115.95±11.37 μm, P < 0.05). Similarly, the superficial retinal vessel length density was significantly lower in the PD group (20.7 [19.62, 22.17] mm(−1)) than in the control group (21.79±1.16 mm(−1), P < 0.05). Correlation analysis revealed a negative correlation between RNFL thickness and UPDRS III score (r(s)=−0.036, P=0.037), and RNFL thickness tended to decrease with increasing severity of movement disorders. However, during the 6 and 12-month follow-up of some PD patients, we observed no progressive thinning of the RNFL or decreased superficial vascular density. CONCLUSION: PD patients show retinal structural damage characterized by RNFL thinning and reduced retinal vessel length density. However, RNFL thickness did not correlate with vascular density nor did it decrease with the disease’s progression.
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spelling pubmed-104602072023-08-27 Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease Tu, Min Yang, Shuangfeng Zeng, Lan Tan, Yuling Wang, Xiaoming Int J Gen Med Original Research OBJECTIVE: This study aims to compare the superficial vascular density from the macular region and the retinal nerve fiber layer (RNFL) thickness from the optic disc region between Parkinson’s disease (PD) patients and controls. METHODS: We enrolled 56 idiopathic PD patients, totaling 86 eyes (PD group), and 45 sex- and age-matched healthy individuals, amounting to 90 eyes (control group). All subjects underwent examination using Zeiss wide-field vascular optical coherence tomography (OCT) (Cirrus HD-OCT 5000 Carl Zeiss, Germany), with a scanning range of 3 mm × 3 mm. We divided the images into two concentric circles with diameters of 1 mm and 3 mm at the macular fovea’s center. Patients with PD were evaluated during their “off” phase using the Unified Parkinson’s Disease Rating Scale III (UPDRS-III) and the Hoehn-Yahr scale (H-Y scale) to assess disease severity. RESULTS: The PD group exhibited significantly lower RNFL thickness (106.13±12.36 μm) compared to the control group (115.95±11.37 μm, P < 0.05). Similarly, the superficial retinal vessel length density was significantly lower in the PD group (20.7 [19.62, 22.17] mm(−1)) than in the control group (21.79±1.16 mm(−1), P < 0.05). Correlation analysis revealed a negative correlation between RNFL thickness and UPDRS III score (r(s)=−0.036, P=0.037), and RNFL thickness tended to decrease with increasing severity of movement disorders. However, during the 6 and 12-month follow-up of some PD patients, we observed no progressive thinning of the RNFL or decreased superficial vascular density. CONCLUSION: PD patients show retinal structural damage characterized by RNFL thinning and reduced retinal vessel length density. However, RNFL thickness did not correlate with vascular density nor did it decrease with the disease’s progression. Dove 2023-08-22 /pmc/articles/PMC10460207/ /pubmed/37637710 http://dx.doi.org/10.2147/IJGM.S426501 Text en © 2023 Tu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tu, Min
Yang, Shuangfeng
Zeng, Lan
Tan, Yuling
Wang, Xiaoming
Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title_full Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title_fullStr Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title_full_unstemmed Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title_short Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease
title_sort retinal vessel density and retinal nerve fiber layer thickness: a prospective study of one-year follow-up of patients with parkinson’s disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460207/
https://www.ncbi.nlm.nih.gov/pubmed/37637710
http://dx.doi.org/10.2147/IJGM.S426501
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