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Radiation treatment methods in uveal melanoma

BACKGROUND: The most frequent primary ocular malignancy in the western world is the uveal melanoma. While it mainly affects Caucasians, it is extremely uncommon among non-Caucasians. Continuous improvement in therapies for local treatment has allowed sparing of the eye, although this approach appare...

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Autores principales: Tsotridou, Eleni, Loukovitis, Eleftherios, Tsiropoulos, Georgios N., Zapsalis, Konstantinos, Pentara, Iro, Tzima, Konstantina, Eminidou, Valeria, Anogeianakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Virtual Ophthalmic Research Center 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460216/
https://www.ncbi.nlm.nih.gov/pubmed/37641625
http://dx.doi.org/10.51329/mehdiophthal1419
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author Tsotridou, Eleni
Loukovitis, Eleftherios
Tsiropoulos, Georgios N.
Zapsalis, Konstantinos
Pentara, Iro
Tzima, Konstantina
Eminidou, Valeria
Anogeianakis, George
author_facet Tsotridou, Eleni
Loukovitis, Eleftherios
Tsiropoulos, Georgios N.
Zapsalis, Konstantinos
Pentara, Iro
Tzima, Konstantina
Eminidou, Valeria
Anogeianakis, George
author_sort Tsotridou, Eleni
collection PubMed
description BACKGROUND: The most frequent primary ocular malignancy in the western world is the uveal melanoma. While it mainly affects Caucasians, it is extremely uncommon among non-Caucasians. Continuous improvement in therapies for local treatment has allowed sparing of the eye, although this approach apparently does not improve survival. The present review aimed to explain different radiotherapy (RT) methods and compare the pros and cons of each method, along with the main complications that may be encountered in the treatment of uveal melanoma. METHODS: Relevant papers published between September 2009 and January 2021 were retrieved, reviewed, and screened. Four databases, including PubMed, MEDLINE, Google Scholar, and GeneCards, were searched for this purpose. RESULTS: Forty-one relevant articles were identified. Based on the selected papers, we highlighted the advantages and disadvantages of the different RT methods that have allowed sparing of the eye, even though they have not, as yet, improved survival. We listed a detailed comparison between therapies that allow an educated choice among the different available RT methods. CONCLUSIONS: The choice of uveal melanoma management is determined by the location of the tumor and volume of the extraocular extent. At present, there is no gold standard for the management of all ocular melanomas, and each case should be approached individually. Therefore, classification is a valuable prognostic tool. Many cases in cT3-4 classification categories are treated by primary enucleation and conservative treatment follow-up, while in cT2 and most cT1 classifications (i.e., 3.1–6.0-mm tumor thickness), several forms of RT are used.
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spelling pubmed-104602162023-08-28 Radiation treatment methods in uveal melanoma Tsotridou, Eleni Loukovitis, Eleftherios Tsiropoulos, Georgios N. Zapsalis, Konstantinos Pentara, Iro Tzima, Konstantina Eminidou, Valeria Anogeianakis, George Med Hypothesis Discov Innov Ophthalmol Review Article BACKGROUND: The most frequent primary ocular malignancy in the western world is the uveal melanoma. While it mainly affects Caucasians, it is extremely uncommon among non-Caucasians. Continuous improvement in therapies for local treatment has allowed sparing of the eye, although this approach apparently does not improve survival. The present review aimed to explain different radiotherapy (RT) methods and compare the pros and cons of each method, along with the main complications that may be encountered in the treatment of uveal melanoma. METHODS: Relevant papers published between September 2009 and January 2021 were retrieved, reviewed, and screened. Four databases, including PubMed, MEDLINE, Google Scholar, and GeneCards, were searched for this purpose. RESULTS: Forty-one relevant articles were identified. Based on the selected papers, we highlighted the advantages and disadvantages of the different RT methods that have allowed sparing of the eye, even though they have not, as yet, improved survival. We listed a detailed comparison between therapies that allow an educated choice among the different available RT methods. CONCLUSIONS: The choice of uveal melanoma management is determined by the location of the tumor and volume of the extraocular extent. At present, there is no gold standard for the management of all ocular melanomas, and each case should be approached individually. Therefore, classification is a valuable prognostic tool. Many cases in cT3-4 classification categories are treated by primary enucleation and conservative treatment follow-up, while in cT2 and most cT1 classifications (i.e., 3.1–6.0-mm tumor thickness), several forms of RT are used. International Virtual Ophthalmic Research Center 2021-05-31 /pmc/articles/PMC10460216/ /pubmed/37641625 http://dx.doi.org/10.51329/mehdiophthal1419 Text en © Author(s). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Review Article
Tsotridou, Eleni
Loukovitis, Eleftherios
Tsiropoulos, Georgios N.
Zapsalis, Konstantinos
Pentara, Iro
Tzima, Konstantina
Eminidou, Valeria
Anogeianakis, George
Radiation treatment methods in uveal melanoma
title Radiation treatment methods in uveal melanoma
title_full Radiation treatment methods in uveal melanoma
title_fullStr Radiation treatment methods in uveal melanoma
title_full_unstemmed Radiation treatment methods in uveal melanoma
title_short Radiation treatment methods in uveal melanoma
title_sort radiation treatment methods in uveal melanoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460216/
https://www.ncbi.nlm.nih.gov/pubmed/37641625
http://dx.doi.org/10.51329/mehdiophthal1419
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