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Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

SIGNIFICANCE: Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of...

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Autores principales: Cheburkanov, Vsevolod, Du, Junwei, Brogan, David M., Berezin, Mikhail Y., Yakovlev, Vladislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460255/
https://www.ncbi.nlm.nih.gov/pubmed/37635849
http://dx.doi.org/10.1117/1.NPh.10.3.035007
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author Cheburkanov, Vsevolod
Du, Junwei
Brogan, David M.
Berezin, Mikhail Y.
Yakovlev, Vladislav V.
author_facet Cheburkanov, Vsevolod
Du, Junwei
Brogan, David M.
Berezin, Mikhail Y.
Yakovlev, Vladislav V.
author_sort Cheburkanov, Vsevolod
collection PubMed
description SIGNIFICANCE: Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures. AIM: We aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury in vivo. APPROACH: Viscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy. RESULTS: An external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties. CONCLUSIONS: Brillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves.
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spelling pubmed-104602552023-08-27 Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy Cheburkanov, Vsevolod Du, Junwei Brogan, David M. Berezin, Mikhail Y. Yakovlev, Vladislav V. Neurophotonics Research Papers SIGNIFICANCE: Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures. AIM: We aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury in vivo. APPROACH: Viscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy. RESULTS: An external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties. CONCLUSIONS: Brillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves. Society of Photo-Optical Instrumentation Engineers 2023-08-26 2023-07 /pmc/articles/PMC10460255/ /pubmed/37635849 http://dx.doi.org/10.1117/1.NPh.10.3.035007 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Research Papers
Cheburkanov, Vsevolod
Du, Junwei
Brogan, David M.
Berezin, Mikhail Y.
Yakovlev, Vladislav V.
Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title_full Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title_fullStr Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title_full_unstemmed Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title_short Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy
title_sort toward peripheral nerve mechanical characterization using brillouin imaging spectroscopy
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460255/
https://www.ncbi.nlm.nih.gov/pubmed/37635849
http://dx.doi.org/10.1117/1.NPh.10.3.035007
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