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The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI s...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460355/ https://www.ncbi.nlm.nih.gov/pubmed/37335320 http://dx.doi.org/10.1007/s00127-023-02513-0 |
| _version_ | 1785097625642467328 |
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| author | Sideli, Lucia Aas, Monica Quattrone, Diego La Barbera, Daniele La Cascia, Caterina Ferraro, Laura Alameda, Luis Velthorst, Eva Trotta, Giulia Tripoli, Giada Schimmenti, Adriano Fontana, Andrea Gayer-Anderson, Charlotte Stilo, Simona Seminerio, Fabio Sartorio, Crocettarachele Marrazzo, Giovanna Lasalvia, Antonio Tosato, Sarah Tarricone, Ilaria Berardi, Domenico D’Andrea, Giuseppe Arango, Celso Arrojo, Manuel Bernardo, Miguel Bobes, Julio Sanjuán, Julio Santos, Jose Luis Menezes, Paulo Rossi Del-Ben, Cristina Marta Jongsma, Hannah E. Jones, Peter B. Kirkbride, James B. Llorca, Pierre-Michel Tortelli, Andrea Pignon, Baptiste de Haan, Lieuwe Selten, Jean-Paul Van Os, Jim Rutten, Bart P. Bentall, Richard Di Forti, Marta Murray, Robin M. Morgan, Craig Fisher, Helen L. |
| author_facet | Sideli, Lucia Aas, Monica Quattrone, Diego La Barbera, Daniele La Cascia, Caterina Ferraro, Laura Alameda, Luis Velthorst, Eva Trotta, Giulia Tripoli, Giada Schimmenti, Adriano Fontana, Andrea Gayer-Anderson, Charlotte Stilo, Simona Seminerio, Fabio Sartorio, Crocettarachele Marrazzo, Giovanna Lasalvia, Antonio Tosato, Sarah Tarricone, Ilaria Berardi, Domenico D’Andrea, Giuseppe Arango, Celso Arrojo, Manuel Bernardo, Miguel Bobes, Julio Sanjuán, Julio Santos, Jose Luis Menezes, Paulo Rossi Del-Ben, Cristina Marta Jongsma, Hannah E. Jones, Peter B. Kirkbride, James B. Llorca, Pierre-Michel Tortelli, Andrea Pignon, Baptiste de Haan, Lieuwe Selten, Jean-Paul Van Os, Jim Rutten, Bart P. Bentall, Richard Di Forti, Marta Murray, Robin M. Morgan, Craig Fisher, Helen L. |
| author_sort | Sideli, Lucia |
| collection | PubMed |
| description | This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-023-02513-0. |
| format | Online Article Text |
| id | pubmed-10460355 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104603552023-08-28 The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study Sideli, Lucia Aas, Monica Quattrone, Diego La Barbera, Daniele La Cascia, Caterina Ferraro, Laura Alameda, Luis Velthorst, Eva Trotta, Giulia Tripoli, Giada Schimmenti, Adriano Fontana, Andrea Gayer-Anderson, Charlotte Stilo, Simona Seminerio, Fabio Sartorio, Crocettarachele Marrazzo, Giovanna Lasalvia, Antonio Tosato, Sarah Tarricone, Ilaria Berardi, Domenico D’Andrea, Giuseppe Arango, Celso Arrojo, Manuel Bernardo, Miguel Bobes, Julio Sanjuán, Julio Santos, Jose Luis Menezes, Paulo Rossi Del-Ben, Cristina Marta Jongsma, Hannah E. Jones, Peter B. Kirkbride, James B. Llorca, Pierre-Michel Tortelli, Andrea Pignon, Baptiste de Haan, Lieuwe Selten, Jean-Paul Van Os, Jim Rutten, Bart P. Bentall, Richard Di Forti, Marta Murray, Robin M. Morgan, Craig Fisher, Helen L. Soc Psychiatry Psychiatr Epidemiol Brief Report This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-023-02513-0. Springer Berlin Heidelberg 2023-06-19 2023 /pmc/articles/PMC10460355/ /pubmed/37335320 http://dx.doi.org/10.1007/s00127-023-02513-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Report Sideli, Lucia Aas, Monica Quattrone, Diego La Barbera, Daniele La Cascia, Caterina Ferraro, Laura Alameda, Luis Velthorst, Eva Trotta, Giulia Tripoli, Giada Schimmenti, Adriano Fontana, Andrea Gayer-Anderson, Charlotte Stilo, Simona Seminerio, Fabio Sartorio, Crocettarachele Marrazzo, Giovanna Lasalvia, Antonio Tosato, Sarah Tarricone, Ilaria Berardi, Domenico D’Andrea, Giuseppe Arango, Celso Arrojo, Manuel Bernardo, Miguel Bobes, Julio Sanjuán, Julio Santos, Jose Luis Menezes, Paulo Rossi Del-Ben, Cristina Marta Jongsma, Hannah E. Jones, Peter B. Kirkbride, James B. Llorca, Pierre-Michel Tortelli, Andrea Pignon, Baptiste de Haan, Lieuwe Selten, Jean-Paul Van Os, Jim Rutten, Bart P. Bentall, Richard Di Forti, Marta Murray, Robin M. Morgan, Craig Fisher, Helen L. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title_full | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title_fullStr | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title_full_unstemmed | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title_short | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study |
| title_sort | relationship between genetic liability, childhood maltreatment, and iq: findings from the eu-gei multicentric case–control study |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460355/ https://www.ncbi.nlm.nih.gov/pubmed/37335320 http://dx.doi.org/10.1007/s00127-023-02513-0 |
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