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Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors

PURPOSES: Physical activity (PA) may mitigate late cardiometabolic toxicity of cisplatin-based chemotherapy in testicular germ cell tumor (TGCT) long-term survivors. In this cross-sectional study, we evaluated the effects of habitual PA on metabolic syndrome (MetS) prevalence, and on the markers of...

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Autores principales: Amiri, Ali, Krumpolec, Patrik, Mego, Michal, Ukropcová, Barbara, Chovanec, Michal, Ukropec, Jozef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460370/
https://www.ncbi.nlm.nih.gov/pubmed/37632597
http://dx.doi.org/10.1007/s00520-023-08000-1
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author Amiri, Ali
Krumpolec, Patrik
Mego, Michal
Ukropcová, Barbara
Chovanec, Michal
Ukropec, Jozef
author_facet Amiri, Ali
Krumpolec, Patrik
Mego, Michal
Ukropcová, Barbara
Chovanec, Michal
Ukropec, Jozef
author_sort Amiri, Ali
collection PubMed
description PURPOSES: Physical activity (PA) may mitigate late cardiometabolic toxicity of cisplatin-based chemotherapy in testicular germ cell tumor (TGCT) long-term survivors. In this cross-sectional study, we evaluated the effects of habitual PA on metabolic syndrome (MetS) prevalence, and on the markers of cardiometabolic health and chronic inflammation in a population of long-term TGCT survivors. METHODS: MetS prevalence was evaluated, and habitual PA was assessed using Baecke’s habitual PA questionnaire in TGCT survivors (n=195, age=41.1±8.1years, 11.7±5.2years post-therapy) and healthy male controls (n=41, age=38.2±8.8years). Participants were stratified into low- and high-PA groups based on median values. Differences were examined between low- and high-PA groups (in the entire sample, TGCT survivor sub-samples differing in disease stage, and healthy controls), and between TGCT survivors and controls. Next, TGCT survivors were stratified into age- and BMI-matched sub-groups based on post-treatment time (5–15/15/30years) and number of chemotherapy cycles (≤3/>3), allowing us to detect age- and BMI-independent effects of habitual PA on cardiometabolic health in the given TGCT survivor sub-populations. A correlation matrix of habitual PA and sport activity with cardiometabolic and pro-inflammatory markers was generated. RESULTS: TGCT survivors had higher MetS prevalence than controls. Patients with high habitual PA had lower waist circumference and Systemic Inflammation Index. Habitual PA scores correlated positively with HDL-cholesterol and negatively with waist circumference and atherogenic risk. Furthermore, cardiometabolic benefits of habitual PA were more pronounced in patients with disease stages 1 and 2. Effects of habitual PA on patients sub-populations stratified by chemotherapy dose and post-treatment time clearly showed that higher levels of habitual PA were associated with lower numbers of MetS components, except for patients who received more than 3 chemotherapy cycles and were examined more than15 years post-therapy. CONCLUSIONS: Higher levels of habitual PA effectively mitigated cardiometabolic toxicity in TGCT survivors. Patients with higher cumulative doses of chemotherapy may need structured exercise interventions involving higher-intensity physical activity to achieve significant improvements in cardiometabolic health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-08000-1.
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spelling pubmed-104603702023-08-28 Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors Amiri, Ali Krumpolec, Patrik Mego, Michal Ukropcová, Barbara Chovanec, Michal Ukropec, Jozef Support Care Cancer Research PURPOSES: Physical activity (PA) may mitigate late cardiometabolic toxicity of cisplatin-based chemotherapy in testicular germ cell tumor (TGCT) long-term survivors. In this cross-sectional study, we evaluated the effects of habitual PA on metabolic syndrome (MetS) prevalence, and on the markers of cardiometabolic health and chronic inflammation in a population of long-term TGCT survivors. METHODS: MetS prevalence was evaluated, and habitual PA was assessed using Baecke’s habitual PA questionnaire in TGCT survivors (n=195, age=41.1±8.1years, 11.7±5.2years post-therapy) and healthy male controls (n=41, age=38.2±8.8years). Participants were stratified into low- and high-PA groups based on median values. Differences were examined between low- and high-PA groups (in the entire sample, TGCT survivor sub-samples differing in disease stage, and healthy controls), and between TGCT survivors and controls. Next, TGCT survivors were stratified into age- and BMI-matched sub-groups based on post-treatment time (5–15/15/30years) and number of chemotherapy cycles (≤3/>3), allowing us to detect age- and BMI-independent effects of habitual PA on cardiometabolic health in the given TGCT survivor sub-populations. A correlation matrix of habitual PA and sport activity with cardiometabolic and pro-inflammatory markers was generated. RESULTS: TGCT survivors had higher MetS prevalence than controls. Patients with high habitual PA had lower waist circumference and Systemic Inflammation Index. Habitual PA scores correlated positively with HDL-cholesterol and negatively with waist circumference and atherogenic risk. Furthermore, cardiometabolic benefits of habitual PA were more pronounced in patients with disease stages 1 and 2. Effects of habitual PA on patients sub-populations stratified by chemotherapy dose and post-treatment time clearly showed that higher levels of habitual PA were associated with lower numbers of MetS components, except for patients who received more than 3 chemotherapy cycles and were examined more than15 years post-therapy. CONCLUSIONS: Higher levels of habitual PA effectively mitigated cardiometabolic toxicity in TGCT survivors. Patients with higher cumulative doses of chemotherapy may need structured exercise interventions involving higher-intensity physical activity to achieve significant improvements in cardiometabolic health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-08000-1. Springer Berlin Heidelberg 2023-08-26 2023 /pmc/articles/PMC10460370/ /pubmed/37632597 http://dx.doi.org/10.1007/s00520-023-08000-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Amiri, Ali
Krumpolec, Patrik
Mego, Michal
Ukropcová, Barbara
Chovanec, Michal
Ukropec, Jozef
Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title_full Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title_fullStr Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title_full_unstemmed Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title_short Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
title_sort habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460370/
https://www.ncbi.nlm.nih.gov/pubmed/37632597
http://dx.doi.org/10.1007/s00520-023-08000-1
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