Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

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Infections by Clostridioides difficile, a bacterium that targets the large intestine (colon), impact a large number of people worldwide. Bacterial colonization is mediated by two exotoxins: toxins A and B. Short peptides that can be delivered to the gut and inhibit the biocatalytic activity of these...

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Detalles Bibliográficos
Autores principales: Sarma, Sudeep, Catella, Carly M., San Pedro, Ellyce T., Xiao, Xingqing, Durmusoglu, Deniz, Menegatti, Stefano, Crook, Nathan, Magness, Scott T., Hall, Carol K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460389/
https://www.ncbi.nlm.nih.gov/pubmed/37634026
http://dx.doi.org/10.1038/s42003-023-05242-x
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