Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma

The genomic origin and development of the biphasic lung adenosquamous carcinoma (ASC) remain inconclusive. Here, we derived potential evolutionary trajectory of ASC through whole-exome sequencing, Stereo-seq, and patient-derived xenografts. We showed that EGFR and MET activating mutations were the m...

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Detalles Bibliográficos
Autores principales: Zhao, Ruiying, Xu, Yunhua, Chen, Yedan, Zhang, Jiajun, Teng, Fei, Liao, Sha, Chen, Shengnan, Wu, Qian, Xiang, Chan, Pang, Jiaohui, Shang, Zhanxian, Zhao, Jikai, Bao, Hairong, Bao, Hua, Shao, Yang, Lu, Shun, Han, Yuchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460394/
https://www.ncbi.nlm.nih.gov/pubmed/37634047
http://dx.doi.org/10.1038/s41698-023-00430-8

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