Cargando…

The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, and DNA integrity,...

Descripción completa

Detalles Bibliográficos
Autores principales: Walke, Gireeja, Gaurkar, Sagar S, Prasad, Roshan, Lohakare, Tejaswee, Wanjari, Mayur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460465/
https://www.ncbi.nlm.nih.gov/pubmed/37641770
http://dx.doi.org/10.7759/cureus.42583
_version_ 1785097649964187648
author Walke, Gireeja
Gaurkar, Sagar S
Prasad, Roshan
Lohakare, Tejaswee
Wanjari, Mayur
author_facet Walke, Gireeja
Gaurkar, Sagar S
Prasad, Roshan
Lohakare, Tejaswee
Wanjari, Mayur
author_sort Walke, Gireeja
collection PubMed
description Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, and DNA integrity, leading to male infertility. Antioxidants play a crucial role in maintaining reproductive health by neutralizing ROS and protecting sperm cells from oxidative damage. This review article explores the impact of oxidative stress on male reproductive function and investigates the potential benefits of antioxidant supplementation in mitigating its detrimental effects. A comprehensive literature search was conducted to gather relevant studies examining the effects of oxidative stress on male fertility and the outcomes of antioxidant supplementation. The findings reveal that antioxidant supplementation can improve sperm quality, DNA integrity, and fertility outcomes in some individuals. However, conflicting research findings and limitations in study design highlight the need for further investigation. Factors such as individual variations, underlying causes of infertility, dosage, and duration of supplementation should be carefully considered. Lifestyle modifications, including a healthy diet and exercise, are crucial in reducing oxidative stress and optimizing male reproductive health. This review article provides valuable insights into the complex relationship between oxidative stress and male reproductive function, emphasizing the potential role of antioxidant supplementation as a supportive strategy. Further research is warranted to establish optimal protocols, identify specific subgroups that may benefit the most, and explore advancements in antioxidant therapies to improve male fertility outcomes.
format Online
Article
Text
id pubmed-10460465
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-104604652023-08-28 The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation Walke, Gireeja Gaurkar, Sagar S Prasad, Roshan Lohakare, Tejaswee Wanjari, Mayur Cureus Medical Education Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, and DNA integrity, leading to male infertility. Antioxidants play a crucial role in maintaining reproductive health by neutralizing ROS and protecting sperm cells from oxidative damage. This review article explores the impact of oxidative stress on male reproductive function and investigates the potential benefits of antioxidant supplementation in mitigating its detrimental effects. A comprehensive literature search was conducted to gather relevant studies examining the effects of oxidative stress on male fertility and the outcomes of antioxidant supplementation. The findings reveal that antioxidant supplementation can improve sperm quality, DNA integrity, and fertility outcomes in some individuals. However, conflicting research findings and limitations in study design highlight the need for further investigation. Factors such as individual variations, underlying causes of infertility, dosage, and duration of supplementation should be carefully considered. Lifestyle modifications, including a healthy diet and exercise, are crucial in reducing oxidative stress and optimizing male reproductive health. This review article provides valuable insights into the complex relationship between oxidative stress and male reproductive function, emphasizing the potential role of antioxidant supplementation as a supportive strategy. Further research is warranted to establish optimal protocols, identify specific subgroups that may benefit the most, and explore advancements in antioxidant therapies to improve male fertility outcomes. Cureus 2023-07-27 /pmc/articles/PMC10460465/ /pubmed/37641770 http://dx.doi.org/10.7759/cureus.42583 Text en Copyright © 2023, Walke et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Medical Education
Walke, Gireeja
Gaurkar, Sagar S
Prasad, Roshan
Lohakare, Tejaswee
Wanjari, Mayur
The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title_full The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title_fullStr The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title_full_unstemmed The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title_short The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation
title_sort impact of oxidative stress on male reproductive function: exploring the role of antioxidant supplementation
topic Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460465/
https://www.ncbi.nlm.nih.gov/pubmed/37641770
http://dx.doi.org/10.7759/cureus.42583
work_keys_str_mv AT walkegireeja theimpactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT gaurkarsagars theimpactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT prasadroshan theimpactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT lohakaretejaswee theimpactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT wanjarimayur theimpactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT walkegireeja impactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT gaurkarsagars impactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT prasadroshan impactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT lohakaretejaswee impactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation
AT wanjarimayur impactofoxidativestressonmalereproductivefunctionexploringtheroleofantioxidantsupplementation