Adjusting for gene-specific covariates to improve RNA-seq analysis

SUMMARY: This article suggests a novel positive false discovery rate (pFDR) controlling method for testing gene-specific hypotheses using a gene-specific covariate variable, such as gene length. We suppose the null probability depends on the covariate variable. In this context, we propose a rejectio...

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Detalles Bibliográficos
Autores principales: Jeon, Hyeongseon, Lim, Kyu-Sang, Nguyen, Yet, Nettleton, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460482/
https://www.ncbi.nlm.nih.gov/pubmed/37589589
http://dx.doi.org/10.1093/bioinformatics/btad498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460482/
https://www.ncbi.nlm.nih.gov/pubmed/37589589
http://dx.doi.org/10.1093/bioinformatics/btad498

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