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Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome

PURPOSE: The underlying pathophysiology linking psoriasis vulgaris (PV) and metabolic syndrome (MetS) is not fully understood. The present study aimed to investigate the serum level of interleukin (IL)-9 and tissue levels of IL-9 and its receptor in PV patients with MetS and analyze the correlation...

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Autores principales: Yan, Liang, Yu, Chongli, Zhao, Zhenkai, Zhang, Yuan, Wang, Rui, Li, Chengxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460594/
https://www.ncbi.nlm.nih.gov/pubmed/37641663
http://dx.doi.org/10.2147/CCID.S422355
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author Yan, Liang
Yu, Chongli
Zhao, Zhenkai
Zhang, Yuan
Wang, Rui
Li, Chengxin
author_facet Yan, Liang
Yu, Chongli
Zhao, Zhenkai
Zhang, Yuan
Wang, Rui
Li, Chengxin
author_sort Yan, Liang
collection PubMed
description PURPOSE: The underlying pathophysiology linking psoriasis vulgaris (PV) and metabolic syndrome (MetS) is not fully understood. The present study aimed to investigate the serum level of interleukin (IL)-9 and tissue levels of IL-9 and its receptor in PV patients with MetS and analyze the correlation of IL-9 levels with psoriasis disease severity and MetS. METHODS: This study enrolled 75 PV patients with MetS, 57 PV patients without MetS, 20 healthy blood donors, and 7 healthy skin donors. Clinical, socio-demographic, and anthropometric data were obtained from all individuals. Fasting blood glucose, insulin, lipid profile levels, and serum levels of IL-9 and IL-17A were measured. The expression of IL-9 and its receptor in skin specimens in PV patients and healthy controls was determined using immunohistochemistry. Normal human epidermal keratinocytes were stimulated with five pro-inflammatory cytokines (tumor necrosis factor-α, oncostatin M, IL-22, IL-17A, and IL-1α) to establish a psoriatic keratinocyte model and subsequently treated with IL-9. Their mRNA levels of antimicrobial peptides and chemokines were measured using quantitative real-time polymerase chain reaction. RESULTS: Serum level of IL-9 and tissue levels of IL-9 and its receptor were upregulated in PV patients with MetS. IL-9 level was positively correlated to IL-17A level; however, no significant correlation of IL-9 level with psoriasis area severity index was observed. IL-9 level had a positive correlation with the presence of MetS and its components. Correspondingly, IL-9 level positively correlated with waist circumference, body mass index, homeostasis model assessment-insulin resistance, blood pressure, and triglyceride level and negatively correlated with high-density lipoprotein cholesterol level. Additionally, IL-9 stimulated the expression of antimicrobial peptides and chemokines in a psoriatic keratinocyte model. CONCLUSION: Our findings confirmed that higher IL-9 level is associated with PV complicated by MetS, suggesting that IL-9 may be a link between PV and MetS.
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spelling pubmed-104605942023-08-28 Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome Yan, Liang Yu, Chongli Zhao, Zhenkai Zhang, Yuan Wang, Rui Li, Chengxin Clin Cosmet Investig Dermatol Original Research PURPOSE: The underlying pathophysiology linking psoriasis vulgaris (PV) and metabolic syndrome (MetS) is not fully understood. The present study aimed to investigate the serum level of interleukin (IL)-9 and tissue levels of IL-9 and its receptor in PV patients with MetS and analyze the correlation of IL-9 levels with psoriasis disease severity and MetS. METHODS: This study enrolled 75 PV patients with MetS, 57 PV patients without MetS, 20 healthy blood donors, and 7 healthy skin donors. Clinical, socio-demographic, and anthropometric data were obtained from all individuals. Fasting blood glucose, insulin, lipid profile levels, and serum levels of IL-9 and IL-17A were measured. The expression of IL-9 and its receptor in skin specimens in PV patients and healthy controls was determined using immunohistochemistry. Normal human epidermal keratinocytes were stimulated with five pro-inflammatory cytokines (tumor necrosis factor-α, oncostatin M, IL-22, IL-17A, and IL-1α) to establish a psoriatic keratinocyte model and subsequently treated with IL-9. Their mRNA levels of antimicrobial peptides and chemokines were measured using quantitative real-time polymerase chain reaction. RESULTS: Serum level of IL-9 and tissue levels of IL-9 and its receptor were upregulated in PV patients with MetS. IL-9 level was positively correlated to IL-17A level; however, no significant correlation of IL-9 level with psoriasis area severity index was observed. IL-9 level had a positive correlation with the presence of MetS and its components. Correspondingly, IL-9 level positively correlated with waist circumference, body mass index, homeostasis model assessment-insulin resistance, blood pressure, and triglyceride level and negatively correlated with high-density lipoprotein cholesterol level. Additionally, IL-9 stimulated the expression of antimicrobial peptides and chemokines in a psoriatic keratinocyte model. CONCLUSION: Our findings confirmed that higher IL-9 level is associated with PV complicated by MetS, suggesting that IL-9 may be a link between PV and MetS. Dove 2023-08-23 /pmc/articles/PMC10460594/ /pubmed/37641663 http://dx.doi.org/10.2147/CCID.S422355 Text en © 2023 Yan et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Yan, Liang
Yu, Chongli
Zhao, Zhenkai
Zhang, Yuan
Wang, Rui
Li, Chengxin
Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title_full Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title_fullStr Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title_full_unstemmed Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title_short Higher IL-9 Level is Associated with Psoriasis Vulgaris Complicated by Metabolic Syndrome
title_sort higher il-9 level is associated with psoriasis vulgaris complicated by metabolic syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460594/
https://www.ncbi.nlm.nih.gov/pubmed/37641663
http://dx.doi.org/10.2147/CCID.S422355
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