Cargando…

Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus

PURPOSE: This study sought to investigate whether asprosin can be used in the diagnosis of GDM or for diagnostic purposes in high-risk pregnancies, along with a review of other parameters that may be associated with serum asprosin levels. PATIENTS AND METHODS: The study investigated the association...

Descripción completa

Detalles Bibliográficos
Autores principales: Boz, İbrahim Bekir, Aytürk Salt, Semra, Salt, Ömer, Sayın, Niyazi Cenk, Dibirdik, İlker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460609/
https://www.ncbi.nlm.nih.gov/pubmed/37641645
http://dx.doi.org/10.2147/DMSO.S424651
_version_ 1785097673562390528
author Boz, İbrahim Bekir
Aytürk Salt, Semra
Salt, Ömer
Sayın, Niyazi Cenk
Dibirdik, İlker
author_facet Boz, İbrahim Bekir
Aytürk Salt, Semra
Salt, Ömer
Sayın, Niyazi Cenk
Dibirdik, İlker
author_sort Boz, İbrahim Bekir
collection PubMed
description PURPOSE: This study sought to investigate whether asprosin can be used in the diagnosis of GDM or for diagnostic purposes in high-risk pregnancies, along with a review of other parameters that may be associated with serum asprosin levels. PATIENTS AND METHODS: The study investigated the association between gestational diabetes mellitus (GDM) and asprosin levels. A total of 93 participants; 30 patients with GDM, 33 healthy pregnant women with normal glucose tolerance (NGT), and 30 healthy non-diabetic women (control group) at the Endocrinology and Metabolic Diseases outpatient clinic of a tertiary care university hospital were enrolled in the study. Patients with GDM and NGT were examined in terms of GDM between the 24th and 28th week of pregnancy (2nd trimester). Patient data were collected during routine examinations, and asprosin levels were measured using the ELISA method. All participants underwent testing for measurements of serum hemoglobin, insulin, C-peptide, fasting plasma glucose, and glycated hemoglobin (HbA1c) levels following a fasting period of at least eight hours. RESULTS: Asprosin levels were higher in pregnant women with NGT and with GDM versus controls (Control–NGT asprosin, p = 0.001; Control–GDM asprosin, p = 0.001). Pregnant women with GDM had higher asprosin levels than those with NGT (p = 0.001). In detecting GDM in pregnant women, an asprosin cutoff value of >31.709 ng/mL yielded a sensitivity of 93.3%, specificity of 90.9%, positive predictive value of 90.3%, and negative predictive value of 93.75% (p < 0.001). CONCLUSION: Serum asprosin levels can potentially be used as a marker in the diagnosis of GDM.
format Online
Article
Text
id pubmed-10460609
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-104606092023-08-28 Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus Boz, İbrahim Bekir Aytürk Salt, Semra Salt, Ömer Sayın, Niyazi Cenk Dibirdik, İlker Diabetes Metab Syndr Obes Original Research PURPOSE: This study sought to investigate whether asprosin can be used in the diagnosis of GDM or for diagnostic purposes in high-risk pregnancies, along with a review of other parameters that may be associated with serum asprosin levels. PATIENTS AND METHODS: The study investigated the association between gestational diabetes mellitus (GDM) and asprosin levels. A total of 93 participants; 30 patients with GDM, 33 healthy pregnant women with normal glucose tolerance (NGT), and 30 healthy non-diabetic women (control group) at the Endocrinology and Metabolic Diseases outpatient clinic of a tertiary care university hospital were enrolled in the study. Patients with GDM and NGT were examined in terms of GDM between the 24th and 28th week of pregnancy (2nd trimester). Patient data were collected during routine examinations, and asprosin levels were measured using the ELISA method. All participants underwent testing for measurements of serum hemoglobin, insulin, C-peptide, fasting plasma glucose, and glycated hemoglobin (HbA1c) levels following a fasting period of at least eight hours. RESULTS: Asprosin levels were higher in pregnant women with NGT and with GDM versus controls (Control–NGT asprosin, p = 0.001; Control–GDM asprosin, p = 0.001). Pregnant women with GDM had higher asprosin levels than those with NGT (p = 0.001). In detecting GDM in pregnant women, an asprosin cutoff value of >31.709 ng/mL yielded a sensitivity of 93.3%, specificity of 90.9%, positive predictive value of 90.3%, and negative predictive value of 93.75% (p < 0.001). CONCLUSION: Serum asprosin levels can potentially be used as a marker in the diagnosis of GDM. Dove 2023-08-23 /pmc/articles/PMC10460609/ /pubmed/37641645 http://dx.doi.org/10.2147/DMSO.S424651 Text en © 2023 Boz et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Boz, İbrahim Bekir
Aytürk Salt, Semra
Salt, Ömer
Sayın, Niyazi Cenk
Dibirdik, İlker
Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title_full Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title_fullStr Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title_full_unstemmed Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title_short Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
title_sort association between plasma asprosin levels and gestational diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460609/
https://www.ncbi.nlm.nih.gov/pubmed/37641645
http://dx.doi.org/10.2147/DMSO.S424651
work_keys_str_mv AT bozibrahimbekir associationbetweenplasmaasprosinlevelsandgestationaldiabetesmellitus
AT ayturksaltsemra associationbetweenplasmaasprosinlevelsandgestationaldiabetesmellitus
AT saltomer associationbetweenplasmaasprosinlevelsandgestationaldiabetesmellitus
AT sayınniyazicenk associationbetweenplasmaasprosinlevelsandgestationaldiabetesmellitus
AT dibirdikilker associationbetweenplasmaasprosinlevelsandgestationaldiabetesmellitus