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Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases

Endothelial cells (ECs) are widely distributed inside the vascular network, forming a vital barrier between the bloodstream and the walls of blood vessels. These versatile cells serve myriad functions, including the regulation of vascular tension and the management of hemostasis and thrombosis. Infl...

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Autores principales: Xue, Jiaojiao, Zhang, Ziwei, Sun, Yuting, Jin, Di, Guo, Liming, Li, Xiangyan, Zhao, Daqing, Feng, Xiaochun, Qi, Wenxiu, Zhu, Haoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460614/
https://www.ncbi.nlm.nih.gov/pubmed/37641702
http://dx.doi.org/10.2147/JIR.S418166
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author Xue, Jiaojiao
Zhang, Ziwei
Sun, Yuting
Jin, Di
Guo, Liming
Li, Xiangyan
Zhao, Daqing
Feng, Xiaochun
Qi, Wenxiu
Zhu, Haoyu
author_facet Xue, Jiaojiao
Zhang, Ziwei
Sun, Yuting
Jin, Di
Guo, Liming
Li, Xiangyan
Zhao, Daqing
Feng, Xiaochun
Qi, Wenxiu
Zhu, Haoyu
author_sort Xue, Jiaojiao
collection PubMed
description Endothelial cells (ECs) are widely distributed inside the vascular network, forming a vital barrier between the bloodstream and the walls of blood vessels. These versatile cells serve myriad functions, including the regulation of vascular tension and the management of hemostasis and thrombosis. Inflammation constitutes a cascade of biological responses incited by biological, chemical, or physical stimuli. While inflammation is inherently a protective mechanism, dysregulated inflammation can precipitate a host of vascular pathologies. ECs play a critical role in the genesis and progression of vascular inflammation, which has been implicated in the etiology of numerous vascular disorders, such as atherosclerosis, cardiovascular diseases, respiratory diseases, diabetes mellitus, and sepsis. Upon activation, ECs secrete potent inflammatory mediators that elicit both innate and adaptive immune reactions, culminating in inflammation. To date, no comprehensive and nuanced account of the research progress concerning ECs and inflammation in vascular-related maladies exists. Consequently, this review endeavors to synthesize the contributions of ECs to inflammatory processes, delineate the molecular signaling pathways involved in regulation, and categorize and consolidate the various models and treatment strategies for vascular-related diseases. It is our aspiration that this review furnishes cogent experimental evidence supporting the established link between endothelial inflammation and vascular-related pathologies, offers a theoretical foundation for clinical investigations, and imparts valuable insights for the development of therapeutic agents targeting these diseases.
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spelling pubmed-104606142023-08-28 Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases Xue, Jiaojiao Zhang, Ziwei Sun, Yuting Jin, Di Guo, Liming Li, Xiangyan Zhao, Daqing Feng, Xiaochun Qi, Wenxiu Zhu, Haoyu J Inflamm Res Review Endothelial cells (ECs) are widely distributed inside the vascular network, forming a vital barrier between the bloodstream and the walls of blood vessels. These versatile cells serve myriad functions, including the regulation of vascular tension and the management of hemostasis and thrombosis. Inflammation constitutes a cascade of biological responses incited by biological, chemical, or physical stimuli. While inflammation is inherently a protective mechanism, dysregulated inflammation can precipitate a host of vascular pathologies. ECs play a critical role in the genesis and progression of vascular inflammation, which has been implicated in the etiology of numerous vascular disorders, such as atherosclerosis, cardiovascular diseases, respiratory diseases, diabetes mellitus, and sepsis. Upon activation, ECs secrete potent inflammatory mediators that elicit both innate and adaptive immune reactions, culminating in inflammation. To date, no comprehensive and nuanced account of the research progress concerning ECs and inflammation in vascular-related maladies exists. Consequently, this review endeavors to synthesize the contributions of ECs to inflammatory processes, delineate the molecular signaling pathways involved in regulation, and categorize and consolidate the various models and treatment strategies for vascular-related diseases. It is our aspiration that this review furnishes cogent experimental evidence supporting the established link between endothelial inflammation and vascular-related pathologies, offers a theoretical foundation for clinical investigations, and imparts valuable insights for the development of therapeutic agents targeting these diseases. Dove 2023-08-23 /pmc/articles/PMC10460614/ /pubmed/37641702 http://dx.doi.org/10.2147/JIR.S418166 Text en © 2023 Xue et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xue, Jiaojiao
Zhang, Ziwei
Sun, Yuting
Jin, Di
Guo, Liming
Li, Xiangyan
Zhao, Daqing
Feng, Xiaochun
Qi, Wenxiu
Zhu, Haoyu
Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title_full Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title_fullStr Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title_full_unstemmed Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title_short Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases
title_sort research progress and molecular mechanisms of endothelial cells inflammation in vascular-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460614/
https://www.ncbi.nlm.nih.gov/pubmed/37641702
http://dx.doi.org/10.2147/JIR.S418166
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