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Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19

PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-5...

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Autores principales: Shaseb, Elnaz, Ghaffary, Saba, Garjani, Alireza, Zoghi, Elnaz, Maleki Dizaji, Nasrin, Soltani, Somaieh, Sarbakhsh, Parvin, Somi, Mohammad Hossein, Valizadeh, Parya, Taghizadieh, Ali, Faghihdinevari, Masood, Varshochi, Mojtaba, Naghily, Behrooz, Bayatmakoo, Zhinous, Saleh, Parviz, Taghizadeh, Sepehr, Haghdoost, Mehdi, Owaysi, Hamid, Ravanbakhsh Ghavghani, Fatemeh, Tarzamni, Mohammad Kazem, Moradi, Rojin, Javan Ali Azar, Fateme, Shabestari Khiabani, Saeid, Ghazanchaei, Ardavan, Hamedani, Sana, Hatefi, Shahabeddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460805/
https://www.ncbi.nlm.nih.gov/pubmed/37646067
http://dx.doi.org/10.34172/apb.2023.066
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author Shaseb, Elnaz
Ghaffary, Saba
Garjani, Alireza
Zoghi, Elnaz
Maleki Dizaji, Nasrin
Soltani, Somaieh
Sarbakhsh, Parvin
Somi, Mohammad Hossein
Valizadeh, Parya
Taghizadieh, Ali
Faghihdinevari, Masood
Varshochi, Mojtaba
Naghily, Behrooz
Bayatmakoo, Zhinous
Saleh, Parviz
Taghizadeh, Sepehr
Haghdoost, Mehdi
Owaysi, Hamid
Ravanbakhsh Ghavghani, Fatemeh
Tarzamni, Mohammad Kazem
Moradi, Rojin
Javan Ali Azar, Fateme
Shabestari Khiabani, Saeid
Ghazanchaei, Ardavan
Hamedani, Sana
Hatefi, Shahabeddin
author_facet Shaseb, Elnaz
Ghaffary, Saba
Garjani, Alireza
Zoghi, Elnaz
Maleki Dizaji, Nasrin
Soltani, Somaieh
Sarbakhsh, Parvin
Somi, Mohammad Hossein
Valizadeh, Parya
Taghizadieh, Ali
Faghihdinevari, Masood
Varshochi, Mojtaba
Naghily, Behrooz
Bayatmakoo, Zhinous
Saleh, Parviz
Taghizadeh, Sepehr
Haghdoost, Mehdi
Owaysi, Hamid
Ravanbakhsh Ghavghani, Fatemeh
Tarzamni, Mohammad Kazem
Moradi, Rojin
Javan Ali Azar, Fateme
Shabestari Khiabani, Saeid
Ghazanchaei, Ardavan
Hamedani, Sana
Hatefi, Shahabeddin
author_sort Shaseb, Elnaz
collection PubMed
description PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. RESULTS: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO(2) did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.
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spelling pubmed-104608052023-08-29 Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 Shaseb, Elnaz Ghaffary, Saba Garjani, Alireza Zoghi, Elnaz Maleki Dizaji, Nasrin Soltani, Somaieh Sarbakhsh, Parvin Somi, Mohammad Hossein Valizadeh, Parya Taghizadieh, Ali Faghihdinevari, Masood Varshochi, Mojtaba Naghily, Behrooz Bayatmakoo, Zhinous Saleh, Parviz Taghizadeh, Sepehr Haghdoost, Mehdi Owaysi, Hamid Ravanbakhsh Ghavghani, Fatemeh Tarzamni, Mohammad Kazem Moradi, Rojin Javan Ali Azar, Fateme Shabestari Khiabani, Saeid Ghazanchaei, Ardavan Hamedani, Sana Hatefi, Shahabeddin Adv Pharm Bull Short Communication PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. RESULTS: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO(2) did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates. Tabriz University of Medical Sciences 2023-07 2022-07-02 /pmc/articles/PMC10460805/ /pubmed/37646067 http://dx.doi.org/10.34172/apb.2023.066 Text en ©2023 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Short Communication
Shaseb, Elnaz
Ghaffary, Saba
Garjani, Alireza
Zoghi, Elnaz
Maleki Dizaji, Nasrin
Soltani, Somaieh
Sarbakhsh, Parvin
Somi, Mohammad Hossein
Valizadeh, Parya
Taghizadieh, Ali
Faghihdinevari, Masood
Varshochi, Mojtaba
Naghily, Behrooz
Bayatmakoo, Zhinous
Saleh, Parviz
Taghizadeh, Sepehr
Haghdoost, Mehdi
Owaysi, Hamid
Ravanbakhsh Ghavghani, Fatemeh
Tarzamni, Mohammad Kazem
Moradi, Rojin
Javan Ali Azar, Fateme
Shabestari Khiabani, Saeid
Ghazanchaei, Ardavan
Hamedani, Sana
Hatefi, Shahabeddin
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title_full Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title_fullStr Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title_full_unstemmed Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title_short Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
title_sort long and short-term metformin consumption as a potential therapy to prevent complications of covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460805/
https://www.ncbi.nlm.nih.gov/pubmed/37646067
http://dx.doi.org/10.34172/apb.2023.066
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