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Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-5...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460805/ https://www.ncbi.nlm.nih.gov/pubmed/37646067 http://dx.doi.org/10.34172/apb.2023.066 |
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author | Shaseb, Elnaz Ghaffary, Saba Garjani, Alireza Zoghi, Elnaz Maleki Dizaji, Nasrin Soltani, Somaieh Sarbakhsh, Parvin Somi, Mohammad Hossein Valizadeh, Parya Taghizadieh, Ali Faghihdinevari, Masood Varshochi, Mojtaba Naghily, Behrooz Bayatmakoo, Zhinous Saleh, Parviz Taghizadeh, Sepehr Haghdoost, Mehdi Owaysi, Hamid Ravanbakhsh Ghavghani, Fatemeh Tarzamni, Mohammad Kazem Moradi, Rojin Javan Ali Azar, Fateme Shabestari Khiabani, Saeid Ghazanchaei, Ardavan Hamedani, Sana Hatefi, Shahabeddin |
author_facet | Shaseb, Elnaz Ghaffary, Saba Garjani, Alireza Zoghi, Elnaz Maleki Dizaji, Nasrin Soltani, Somaieh Sarbakhsh, Parvin Somi, Mohammad Hossein Valizadeh, Parya Taghizadieh, Ali Faghihdinevari, Masood Varshochi, Mojtaba Naghily, Behrooz Bayatmakoo, Zhinous Saleh, Parviz Taghizadeh, Sepehr Haghdoost, Mehdi Owaysi, Hamid Ravanbakhsh Ghavghani, Fatemeh Tarzamni, Mohammad Kazem Moradi, Rojin Javan Ali Azar, Fateme Shabestari Khiabani, Saeid Ghazanchaei, Ardavan Hamedani, Sana Hatefi, Shahabeddin |
author_sort | Shaseb, Elnaz |
collection | PubMed |
description | PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. RESULTS: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO(2) did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates. |
format | Online Article Text |
id | pubmed-10460805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-104608052023-08-29 Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 Shaseb, Elnaz Ghaffary, Saba Garjani, Alireza Zoghi, Elnaz Maleki Dizaji, Nasrin Soltani, Somaieh Sarbakhsh, Parvin Somi, Mohammad Hossein Valizadeh, Parya Taghizadieh, Ali Faghihdinevari, Masood Varshochi, Mojtaba Naghily, Behrooz Bayatmakoo, Zhinous Saleh, Parviz Taghizadeh, Sepehr Haghdoost, Mehdi Owaysi, Hamid Ravanbakhsh Ghavghani, Fatemeh Tarzamni, Mohammad Kazem Moradi, Rojin Javan Ali Azar, Fateme Shabestari Khiabani, Saeid Ghazanchaei, Ardavan Hamedani, Sana Hatefi, Shahabeddin Adv Pharm Bull Short Communication PURPOSE: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. METHODS: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. RESULTS: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO(2) did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates. Tabriz University of Medical Sciences 2023-07 2022-07-02 /pmc/articles/PMC10460805/ /pubmed/37646067 http://dx.doi.org/10.34172/apb.2023.066 Text en ©2023 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers. |
spellingShingle | Short Communication Shaseb, Elnaz Ghaffary, Saba Garjani, Alireza Zoghi, Elnaz Maleki Dizaji, Nasrin Soltani, Somaieh Sarbakhsh, Parvin Somi, Mohammad Hossein Valizadeh, Parya Taghizadieh, Ali Faghihdinevari, Masood Varshochi, Mojtaba Naghily, Behrooz Bayatmakoo, Zhinous Saleh, Parviz Taghizadeh, Sepehr Haghdoost, Mehdi Owaysi, Hamid Ravanbakhsh Ghavghani, Fatemeh Tarzamni, Mohammad Kazem Moradi, Rojin Javan Ali Azar, Fateme Shabestari Khiabani, Saeid Ghazanchaei, Ardavan Hamedani, Sana Hatefi, Shahabeddin Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title | Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title_full | Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title_fullStr | Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title_full_unstemmed | Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title_short | Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19 |
title_sort | long and short-term metformin consumption as a potential therapy to prevent complications of covid-19 |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460805/ https://www.ncbi.nlm.nih.gov/pubmed/37646067 http://dx.doi.org/10.34172/apb.2023.066 |
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